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2ZU2

complex structure of CoV 229E 3CL protease with EPDTC

Summary for 2ZU2
Entry DOI10.2210/pdb2zu2/pdb
Related2ZTX 2ZTY 2ZTZ 2ZU1 2ZU3 2ZU4 2ZU5
Descriptor3C-like proteinase, (4S)-2-METHYL-2,4-PENTANEDIOL, zinc(II)hydrogensulfide, ... (4 entities in total)
Functional Keywordsprotease-inhibitor complex, hydrolase, metal-binding, protease, thiol protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman coronavirus (HCoV-229E)
Cellular locationNon-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U2
Total number of polymer chains2
Total formula weight66548.44
Authors
Lee, C.C.,Wang, A.H.-J. (deposition date: 2008-10-12, release date: 2009-01-13, Last modification date: 2023-11-01)
Primary citationLee, C.C.,Kuo, C.J.,Ko, T.P.,Hsu, M.F.,Tsui, Y.C.,Chang, S.C.,Yang, S.,Chen, S.J.,Chen, H.C.,Hsu, M.C.,Shih, S.R.,Liang, P.H.,Wang, A.H.-J.
Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
J.Biol.Chem., 284:7646-7655, 2009
Cited by
PubMed: 19144641
DOI: 10.1074/jbc.M807947200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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