6JP7

Human antibody 32D6 Fab in complex with PEG

Summary for 6JP7

• Entry DOI: 10.2210/pdb6jp7/pdb
• Descriptor: immunoglobulin Fab heavy chain, immunoglobulin Fab light chain, HEXAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: antibody fab, influenza hemagglutinin, complex structure, specific binding, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 49603.19

Authors

Lee, C.C.,Ko, T.P.,Lin, L.L.,Wang, A.H.J. (deposition date: 2019-03-26, release date: 2020-02-05, Last modification date: 2024-11-06)

Primary citation

Lee, C.C.,Su, Y.C.,Ko, T.P.,Lin, L.L.,Yang, C.Y.,Chang, S.S.,Roffler, S.R.,Wang, A.H.
Structural basis of polyethylene glycol recognition by antibody.
J.Biomed.Sci., 27:12-12, 2020

PubMed Abstract: Polyethylene glycol (PEG) is widely used in industry and medicine. Anti-PEG antibodies have been developed for characterizing PEGylated drugs and other applications. However, the underlying mechanism for specific PEG binding has not been elucidated.

PubMed: 31907057
DOI: 10.1186/s12929-019-0589-7

Experimental method

X-RAY DIFFRACTION (1.909 Å)