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PDB: 62 results

5J3H
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BU of 5j3h by Molmil
Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lawrence, M, Menting, J, Lawrence, C.
Deposit date:2016-03-30
Release date:2016-06-15
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
J.Biol.Chem., 291, 2016
8DI2
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BU of 8di2 by Molmil
Site 2 insulin receptor binding peptide IM459N21
Descriptor: Site 2 binding peptide IM459N21
Authors:Lawrence, M.C, Hu, H, Martinez, F.J, Espinosa, J.F.
Deposit date:2022-06-28
Release date:2022-11-09
Method:SOLUTION NMR
Cite:Activation of the human insulin receptor by non-insulin-related peptides.
Nat Commun, 13, 2022
5KQV
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BU of 5kqv by Molmil
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ...
Authors:Lawrence, M.C, Smith, B.J, Croll, T.I.
Deposit date:2016-07-06
Release date:2017-07-19
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
5JYQ
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BU of 5jyq by Molmil
Structure of Conus Geographus insulin G1
Descriptor: Insulin 1, Insulin 1b, SULFATE ION
Authors:Lawrence, M.C, Menting, J, Norton, R.S, Safavi-Hemami, H.
Deposit date:2016-05-15
Release date:2016-09-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.
Nat.Struct.Mol.Biol., 23, 2016
2PHL
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BU of 2phl by Molmil
THE STRUCTURE OF PHASEOLIN AT 2.2 ANGSTROMS RESOLUTION: IMPLICATIONS FOR A COMMON VICILIN(SLASH)LEGUMIN STRUCTURE AND THE GENETIC ENGINEERING OF SEED STORAGE PROTEINS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHASEOLIN, PHOSPHATE ION
Authors:Lawrence, M.C, Izard, T, Beuchat, M, Blagrove, R.J, Colman, P.M.
Deposit date:1994-07-07
Release date:1994-09-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins.
J.Mol.Biol., 238, 1994
4OGA
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BU of 4oga by Molmil
Insulin in complex with Site 1 of the human insulin receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Menting, J.G.
Deposit date:2014-01-15
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
2BMB
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BU of 2bmb by Molmil
X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from Saccharomyces cerevisiae
Descriptor: FOLIC ACID SYNTHESIS PROTEIN FOL1, PTERIN-6-YL-METHYL-MONOPHOSPHATE
Authors:Lawrence, M.C, Iliades, P, Fernley, R.T, Berglez, J, Pilling, P.A, Macreadie, I.G.
Deposit date:2005-03-11
Release date:2006-01-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Three-Dimensional Structure of the Bifunctional 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase/Dihydropteroate Synthase of Saccharomyces Cerevisiae
J.Mol.Biol., 348, 2005
1G5G
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BU of 1g5g by Molmil
FRAGMENT OF FUSION PROTEIN FROM NEWCASTLE DISEASE VIRUS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Lawrence, M.C, Smith, B.J.
Deposit date:2000-11-01
Release date:2002-02-27
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.
Structure, 9, 2001
5U8R
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BU of 5u8r by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
Authors:Lawrence, M, Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.00001621 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
5U8Q
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BU of 5u8q by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
Authors:Lawrence, M, Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.2710402 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
1PSZ
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BU of 1psz by Molmil
PNEUMOCOCCAL SURFACE ANTIGEN PSAA
Descriptor: PROTEIN (SURFACE ANTIGEN PSAA), ZINC ION
Authors:Lawrence, M.C, Pilling, P.A, Epa, V.C, Berry, A.M, Ogunniyi, A.D, Paton, J.C.
Deposit date:1998-10-13
Release date:2000-04-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein.
Structure, 6, 1998
5EMS
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BU of 5ems by Molmil
Crystal Structure of an iodinated insulin analog
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Lawrence, M.C, Pandyarajan, V, Wan, Z, Weiss, M.A.
Deposit date:2015-11-06
Release date:2016-11-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
J. Biol. Chem., 291, 2016
1FDY
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BU of 1fdy by Molmil
N-ACETYLNEURAMINATE LYASE IN COMPLEX WITH HYDROXYPYRUVATE
Descriptor: 3-HYDROXYPYRUVIC ACID, N-ACETYLNEURAMINATE LYASE
Authors:Lawrence, M.C, Barbosa, J.A.R.G, Smith, B.J, Hall, N.E, Pilling, P.A, Ooi, H.C, Marcuccio, S.M.
Deposit date:1996-07-08
Release date:1997-10-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase.
J.Mol.Biol., 266, 1997
1FDZ
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BU of 1fdz by Molmil
N-ACETYLNEURAMINATE LYASE IN COMPLEX WITH PYRUVATE VIA BOROHYDRIDE REDUCTION
Descriptor: N-ACETYLNEURAMINATE LYASE, PYRUVIC ACID
Authors:Lawrence, M.C, Barbosa, J.A.R.G, Smith, B.J, Hall, N.E, Pilling, P.A, Ooi, H.C, Marcuccio, S.M.
Deposit date:1996-07-08
Release date:1997-10-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase.
J.Mol.Biol., 266, 1997
1PHS
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BU of 1phs by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF THE SEED STORAGE PROTEIN PHASEOLIN AT 3 ANGSTROMS RESOLUTION
Descriptor: PHASEOLIN, BETA-TYPE PRECURSOR
Authors:Lawrence, M.C, Suzuki, E, Varghese, J.N, Davis, P.C, Vandonkelaar, A, Tulloch, P.A, Colman, P.M.
Deposit date:1990-03-21
Release date:1990-10-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.
EMBO J., 9, 1990
1V2I
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BU of 1v2i by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
Deposit date:2003-10-16
Release date:2004-02-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3B
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BU of 1v3b by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
Deposit date:2003-10-30
Release date:2004-02-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3C
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BU of 1v3c by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
Deposit date:2003-10-30
Release date:2004-02-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3E
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BU of 1v3e by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with ZANAMAVIR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
Deposit date:2003-10-30
Release date:2004-02-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3D
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BU of 1v3d by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC2EN
Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
Deposit date:2003-10-30
Release date:2004-02-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
7KD6
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BU of 7kd6 by Molmil
Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lawrence, M.C, Menting, J.G.
Deposit date:2020-10-08
Release date:2021-10-13
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Biophys.J., 2022
3W11
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BU of 3w11 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
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BU of 3w13 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J, Brzozowski, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.303 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
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BU of 3w12 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J, Brzozowsk, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
6VEP
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BU of 6vep by Molmil
Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lawrence, M.C, Menting, J.G.T.
Deposit date:2020-01-02
Release date:2020-06-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020

 

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