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PDB: 152 件
2PEY
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Crystal structure of deletion mutant of APS-kinase domain of human PAPS-synthetase 1
分子名称: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1)
著者Sekulic, N, Lavie, A.
登録日2007-04-03
公開日2007-05-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation.
J.Biol.Chem., 282, 2007
2PEZ
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Crystal structrue of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP
分子名称: (2S,3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-({[(R)-HYDROXY(SULFOOXY)PHOSPHORYL]OXY}METHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL 2-OXIDE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1)
著者Sekulic, N, Lavie, A.
登録日2007-04-03
公開日2007-05-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation.
J.Biol.Chem., 282, 2007
2A30
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Crystal structure of human deoxycytidine kinase in complex with deoxycytidine
分子名称: 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase
著者Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A.
登録日2005-06-23
公開日2006-01-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
2NO6
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C4S dCK variant of dCK in complex with FTC+ADP
分子名称: 4-AMINO-5-FLUORO-1-[(2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-25
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2NO0
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C4S dCK variant of dCK in complex with gemcitabine+ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, GEMCITABINE
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-24
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2NO1
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C4S dCK variant of dCK in complex with D-dC+ADP
分子名称: 2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-24
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2OFW
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BU of 2ofw by Molmil
Crystal structure of the APSK domain of human PAPSS1 complexed with 2 APS molecules
分子名称: ADENOSINE-5'-PHOSPHOSULFATE, APS kinase domain of the PAPS synthetase 1, MAGNESIUM ION
著者Sekulic, N, Lavie, A.
登録日2007-01-04
公開日2007-04-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Elucidation of the Active Conformation of the APS-Kinase Domain of Human PAPS Synthetase 1.
J.Mol.Biol., 367, 2007
2NO9
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The structure of deoxycytidine kinase complexed with troxacitabine and ADP.
分子名称: 4-AMINO-1-[(2S,4S)-2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL]PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Lavie, A.
登録日2006-10-25
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.
Nucleic Acids Res., 35, 2007
2NOA
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The structure of deoxycytidine kinase complexed with lamivudine and ADP.
分子名称: 4-AMINO-1-[(2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Lavie, A.
登録日2006-10-25
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.
Nucleic Acids Res., 35, 2007
2NO7
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C4S dCK variant of dCK in complex with L-dC+ADP
分子名称: 4-AMINO-1-(2-DEOXY-BETA-L-ERYTHRO-PENTOFURANOSYL)PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-25
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2QJF
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BU of 2qjf by Molmil
Crystal structure of ATP-sulfurylase domain of human PAPS synthetase 1
分子名称: ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1, POTASSIUM ION
著者Sekulic, N, Lavie, A.
登録日2007-07-07
公開日2008-11-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献ATP-sulfurylase domain of human bifunctional PAPS-synthetase oscillates between dimeric and monomeric forms
To be Published
1P6X
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Crystal structure of EHV4-TK complexed with Thy and SO4
分子名称: SULFATE ION, THYMIDINE, Thymidine kinase
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P75
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Crystal structure of EHV4-TK complexed with TP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, Thymidine kinase
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1KGD
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BU of 1kgd by Molmil
Crystal Structure of the Guanylate Kinase-like Domain of Human CASK
分子名称: FORMIC ACID, PERIPHERAL PLASMA MEMBRANE CASK
著者Li, Y, Spangenberg, O, Paarmann, I, Konrad, M, Lavie, A.
登録日2001-11-26
公開日2001-12-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.314 Å)
主引用文献Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
J.Biol.Chem., 277, 2002
1LVG
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BU of 1lvg by Molmil
Crystal structure of mouse guanylate kinase in complex with GMP and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, ...
著者Sekulic, N, Shuvalova, L, Spangenberg, O, Konrad, M, Lavie, A.
登録日2002-05-28
公開日2002-12-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural characterization of the closed conformation of mouse guanylate kinase.
J.Biol.Chem., 277, 2002
1P7C
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Crystal Structure of HSV1-TK complexed with TP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, THYMIDINE, ...
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-05-01
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1NN0
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BU of 1nn0 by Molmil
Crystal structure of human thymidylate kinase with ddTMP and ADP
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN5
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BU of 1nn5 by Molmil
Crystal structure of human thymidylate kinase with d4TMP + AppNHp
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMZ
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Crystal structure of human thymidylate kinase with NH2TMP and AppNHp
分子名称: 3'-DEOXY-3'-AMINOTHYMIDINE MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMY
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BU of 1nmy by Molmil
Crystal structure of human thymidylate kinase with FLTMP and AppNHp
分子名称: 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMX
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Crystal structure of human thymidylate kinase with FLTMP and ADP
分子名称: 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN1
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BU of 1nn1 by Molmil
Crystal structure of human thymidylate kinase with ddTMP and AppNHp
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN3
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Crystal structure of human thymidylate kinase with d4TMP + ADP
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1P62
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Structure of human dCK complexed with gemcitabine and ADP-MG
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, GEMCITABINE, ...
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
1P61
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Structure of human dCK complexed with 2'-Deoxycytidine and ADP, P 43 21 2 space group
分子名称: 2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003

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