2ZI5
 
 | | C4S dCK variant of dCK in complex with L-dA+UDP | | 分子名称: | (2S,3R,5S)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Sabini, E, Lavie, A. | | 登録日 | 2008-02-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
|
|
2ZI9
 | |
4JLM
 | | Human dCK C4S-S74E mutant in complex with UDP and the F2.3.1 inhibitor (2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE) | | 分子名称: | 2-[({5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Nomme, J, Lavie, A. | | 登録日 | 2013-03-12 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr.,Sect.D, 70, 2014
|
|
2ZI7
 | | C4S dCK variant of dCK in complex with D-dG+UDP | | 分子名称: | 2'-DEOXY-GUANOSINE, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Sabini, E, Lavie, A. | | 登録日 | 2008-02-13 | | 公開日 | 2008-07-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
J.Med.Chem., 51, 2008
|
|
4JLJ
 | | Human dCK C4S-S74E mutant in complex with UDP and the F2.1.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE) | | 分子名称: | 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Nomme, J, Lavie, A. | | 登録日 | 2013-03-12 | | 公開日 | 2014-01-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr.,Sect.D, 70, 2014
|
|
2ZI3
 | |
2ZI4
 | | C4S dCK variant of dCK in complex with L-dA+ADP | | 分子名称: | (2S,3R,5S)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, ... | | 著者 | Sabini, E, Lavie, A. | | 登録日 | 2008-02-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
|
|
3TSW
 | |
3U80
 | | 1.60 Angstrom Resolution Crystal Structure of a 3-Dehydroquinate Dehydratase-like Protein from Bifidobacterium longum | | 分子名称: | 3-dehydroquinate dehydratase, type II | | 著者 | Light, S.H, Minasov, G, Shuvalova, L, Papazisi, L, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2011-10-14 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of a type II dehydroquinate dehydratase-like protein from Bifidobacterium longum.
J.Struct.Funct.Genom., 14, 2013
|
|
3QEJ
 | | S74E-dCK mutant in complex with UDP | | 分子名称: | Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Hazra, S, Lavie, A. | | 登録日 | 2011-01-20 | | 公開日 | 2011-03-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
|
|
3LH5
 | |
3MJR
 | | Human dCK complex with Acyclic Nucleoside | | 分子名称: | 9-HYROXYETHOXYMETHYLGUANINE, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Hazra, S, Lavie, A. | | 登録日 | 2010-04-13 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.
J.Med.Chem., 53, 2010
|
|
2QQ0
 | | Thymidine Kinase from Thermotoga Maritima in complex with thymidine + AppNHp | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S. | | 登録日 | 2007-07-25 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
|
|
4ECD
 | | 2.5 Angstrom Resolution Crystal Structure of Bifidobacterium longum Chorismate Synthase | | 分子名称: | CHLORIDE ION, Chorismate synthase | | 著者 | Light, S.H, Minasov, G, Krishna, S.N, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2012-03-26 | | 公開日 | 2012-04-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | 2.5 Angstrom Resolution Crystal Structure of Bifidobacterium longum Chorismate Synthase
TO BE PUBLISHED
|
|
4GFS
 | | 1.8 Angstrom Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 with Nickel Bound at Active Site | | 分子名称: | 3-dehydroquinate dehydratase, NICKEL (II) ION, SUCCINIC ACID | | 著者 | Light, S.H, Minasov, G, Krishna, S.N, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2012-08-03 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | 1.8 Angstrom Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 with Nickel Bound at Active Site
TO BE PUBLISHED
|
|
2ORW
 | | Thermotoga maritima thymidine kinase 1 like enzyme in complex with TP4A | | 分子名称: | MAGNESIUM ION, P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ... | | 著者 | Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A. | | 登録日 | 2007-02-04 | | 公開日 | 2007-03-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
|
|
2QQE
 | | Thymidine Kinase from Thermotoga Maritima in complex with Thymidine | | 分子名称: | THYMIDINE, Thymidine kinase, ZINC ION | | 著者 | Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S. | | 登録日 | 2007-07-26 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
|
|
3KFX
 | | Human dCK complex with 5-Me dC and ADP | | 分子名称: | 5-METHYL-2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase | | 著者 | Hazra, S, Lavie, A. | | 登録日 | 2009-10-28 | | 公開日 | 2010-09-15 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues .
Biochemistry, 49, 2010
|
|
2QPO
 | | Thermotoga Maritima Thymidine Kinase in the apo form | | 分子名称: | SULFATE ION, Thymidine kinase, ZINC ION | | 著者 | Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S. | | 登録日 | 2007-07-24 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
|
|
2ORV
 | | human Thymidine Kinase 1 in complex with TP4A | | 分子名称: | P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ZINC ION | | 著者 | Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A. | | 登録日 | 2007-02-04 | | 公開日 | 2007-03-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
|
|
1WPA
 | |
1XAW
 | |
2A2Z
 | | Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate | | 分子名称: | 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ... | | 著者 | Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A. | | 登録日 | 2005-06-23 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
|
|
2OFX
 | |
1VF6
 | | 2.1 Angstrom crystal structure of the PALS-1-L27N and PATJ L27 heterodimer complex | | 分子名称: | MAGUK p55 subfamily member 5, PALS1-associated tight junction protein | | 著者 | Li, Y, Lavie, A, Margolis, B, Karnak, D. | | 登録日 | 2004-04-09 | | 公開日 | 2004-04-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes.
Embo J., 23, 2004
|
|
