4L5B

Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor

Summary for 4L5B

• Entry DOI: 10.2210/pdb4l5b/pdb
• Related: 4JLK
• Descriptor: Deoxycytidine kinase, 1-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: phosphoryl transfer, phosphorylation, deoxycytidine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27707
• Total number of polymer chains: 2
• Total formula weight: 67162.83

Authors

Nomme, J.,Lavie, A. (deposition date: 2013-06-10, release date: 2013-09-18, Last modification date: 2023-09-20)

• Primary citation: Murphy, J.M.,Armijo, A.L.,Nomme, J.,Lee, C.H.,Smith, Q.A.,Li, Z.,Campbell, D.O.,Liao, H.I.,Nathanson, D.A.,Austin, W.R.,Lee, J.T.,Darvish, R.,Wei, L.,Wang, J.,Su, Y.,Damoiseaux, R.,Sadeghi, S.,Phelps, M.E.,Herschman, H.R.,Czernin, J.,Alexandrova, A.N.,Jung, M.E.,Lavie, A.,Radu, C.G.; Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.; J.Med.Chem., 56:6696-6708, 2013; PubMed: 23947754; DOI: 10.1021/jm400457y

Experimental method

X-RAY DIFFRACTION (1.94 Å)