4JLK
Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
Summary for 4JLK
Entry DOI | 10.2210/pdb4jlk/pdb |
Related | 4jlj 4JLM 4JLN |
Descriptor | Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, ... (4 entities in total) |
Functional Keywords | phosphoryl transfer, phosphorylation, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P27707 |
Total number of polymer chains | 2 |
Total formula weight | 67897.62 |
Authors | |
Primary citation | Murphy, J.M.,Armijo, A.L.,Nomme, J.,Lee, C.H.,Smith, Q.A.,Li, Z.,Campbell, D.O.,Liao, H.I.,Nathanson, D.A.,Austin, W.R.,Lee, J.T.,Darvish, R.,Wei, L.,Wang, J.,Su, Y.,Damoiseaux, R.,Sadeghi, S.,Phelps, M.E.,Herschman, H.R.,Czernin, J.,Alexandrova, A.N.,Jung, M.E.,Lavie, A.,Radu, C.G. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J.Med.Chem., 56:6696-6708, 2013 Cited by PubMed: 23947754DOI: 10.1021/jm400457y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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