4JLJ

Human dCK C4S-S74E mutant in complex with UDP and the F2.1.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)

Summary for 4JLJ

• Entry DOI: 10.2210/pdb4jlj/pdb
• Related: 4JLK 4JLM
• Descriptor: Deoxycytidine kinase, 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: phosphoryl transfer, phosphorylation, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27707
• Total number of polymer chains: 2
• Total formula weight: 67841.52

Authors

Nomme, J.,Lavie, A. (deposition date: 2013-03-12, release date: 2014-01-22, Last modification date: 2023-09-20)

• Primary citation: Nomme, J.,Murphy, J.M.,Su, Y.,Sansone, N.D.,Armijo, A.L.,Olson, S.T.,Radu, C.,Lavie, A.; Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.; Acta Crystallogr.,Sect.D, 70:68-78, 2014; PubMed: 24419380; DOI: 10.1107/S1399004713025030

Experimental method

X-RAY DIFFRACTION (2 Å)