8WMH
| Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate | 分子名称: | NTS, TS, deadCbCas9, ... | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | 登録日 | 2023-10-03 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WR4
| Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (non-targeting complex) | 分子名称: | CbCas9 effector-1, DNA (62-MER), MAGNESIUM ION, ... | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | 登録日 | 2023-10-13 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WMM
| Structure of CbCas9-PcrIIC1 complex bound to 28-bp DNA substrate (20-nt complementary) | 分子名称: | MAGNESIUM ION, NTS, PcrIIC1, ... | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | 登録日 | 2023-10-04 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WMN
| Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (symmetric 20-nt complementary) | 分子名称: | DNA (62-MER), MAGNESIUM ION, PcrIIC1, ... | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | 登録日 | 2023-10-04 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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1N6J
| Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2 | 分子名称: | 5'-D(*AP*GP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*CP*T)-3', Calcineurin-binding protein Cabin 1, ... | 著者 | Han, A, Pan, F, Stroud, J.C, Youn, H.D, Liu, J.O, Chen, L. | 登録日 | 2002-11-11 | 公開日 | 2003-11-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 Nature, 422, 2003
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2YP3
| Haemagglutinin of 2004 Human H3N2 Virus in Complex with Human Receptor Analogue 6SLN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Xiong, X, Lin, Y.P, Wharton, S.A, Martin, S.R, Coombs, P.J, Vachieri, S.G, Christodoulou, E, Walker, P.A, Liu, J, Skehel, J.J, Gamblin, S.J, Hay, A.J, Daniels, R.S, McCauley, J.W. | 登録日 | 2012-10-29 | 公開日 | 2012-11-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Evolution of the Receptor Binding Properties of the Influenza A(H3N2) Hemagglutinin. Proc.Natl.Acad.Sci.USA, 109, 2012
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2YP4
| Haemagglutinin of 2004 Human H3N2 Virus in Complex with Human Receptor Analogue LSTc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEMAGGLUTININ, ... | 著者 | Xiong, X, Lin, Y.P, Wharton, S.A, Martin, S.R, Coombs, P.J, Vachieri, S.G, Christodoulou, E, Walker, P.A, Liu, J, Skehel, J.J, Gamblin, S.J, Hay, A.J, Daniels, R.S, McCauley, J.W. | 登録日 | 2012-10-29 | 公開日 | 2012-11-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Evolution of the Receptor Binding Properties of the Influenza A(H3N2) Hemagglutinin. Proc.Natl.Acad.Sci.USA, 109, 2012
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5K0K
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434 | 分子名称: | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]te traazacyclotetradecin-8(3H)-one, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Wang, X, Liu, J, Zhang, W, Stashko, M.A, Nichols, J, DeRyckere, D, Miley, M.J, Norris-Drouin, J, Chen, Z, Machius, M, Wood, E, Graham, D.K, Earp, H.S, Graham, K, Kireev, D, Frye, S.V. | 登録日 | 2016-05-17 | 公開日 | 2017-01-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.545 Å) | 主引用文献 | Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS Med Chem Lett, 7, 2016
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4G42
| Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D | 分子名称: | 8-MERIC PEPTIDE P8D, Beta-2 microglobulin, MHC class I alpha chain 2 | 著者 | Zhang, J, Chen, Y, Qi, J, Gao, F, Liu, J, Kaufman, J, Xia, C, Gao, G.F. | 登録日 | 2012-07-16 | 公開日 | 2012-11-21 | 実験手法 | X-RAY DIFFRACTION (2.294 Å) | 主引用文献 | Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens. J.Immunol., 189, 2012
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8EB7
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8EAO
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1WBY
| CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE | 分子名称: | BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | 著者 | Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L. | 登録日 | 2004-11-05 | 公開日 | 2005-01-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance J.Mol.Biol., 345, 2005
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1VKJ
| Crystal structure of heparan sulfate 3-O-sulfotransferase isoform 1 in the presence of PAP | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, SULFATE ION, heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 著者 | Thorp, S, Lee, K.A, Negishi, M, Linhardt, R.J, Liu, J, Pedersen, L.C. | 登録日 | 2004-05-25 | 公開日 | 2004-06-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1 J.Biol.Chem., 279, 2004
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4G43
| Structure of the chicken MHC class I molecule BF2*0401 complexed to P5E | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-MERIC PEPTIDE P5E, Beta-2 microglobulin, ... | 著者 | Zhang, J, Chen, Y, Qi, J, Gao, F, Liu, J, Kaufman, J, Xia, C, Gao, G.F. | 登録日 | 2012-07-16 | 公開日 | 2012-11-21 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens. J.Immunol., 189, 2012
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2Z6H
| Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain | 分子名称: | Catenin beta-1 | 著者 | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | 登録日 | 2007-08-01 | 公開日 | 2008-02-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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2Z6G
| Crystal Structure of a Full-Length Zebrafish Beta-Catenin | 分子名称: | B-catenin | 著者 | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | 登録日 | 2007-08-01 | 公開日 | 2008-02-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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6VRU
| PIM-inhibitor complex 1 | 分子名称: | 3,4-dichloro-2-cyclopropyl-1-[(piperidin-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridine-6-carboxamide, ACETATE ION, IMIDAZOLE, ... | 著者 | Barberis, C.E, Batchelor, J.D, Mechin, I, Liu, J. | 登録日 | 2020-02-10 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg.Med.Chem.Lett., 30, 2020
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6VRV
| Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model | 分子名称: | 4-chloro-1-{(1S)-1-[(3S)-3-fluoropyrrolidin-3-yl]ethyl}-3-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxamide, GLYCEROL, Serine/threonine-protein kinase pim-1 | 著者 | Barberis, C.E, Batchelor, J.D, Liu, J. | 登録日 | 2020-02-10 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg.Med.Chem.Lett., 30, 2020
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1WBZ
| CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE | 分子名称: | BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN PRECURSOR, ... | 著者 | Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L. | 登録日 | 2004-11-05 | 公開日 | 2005-01-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance J.Mol.Biol., 345, 2005
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1WBX
| CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE | 分子名称: | BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | 著者 | Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L. | 登録日 | 2004-11-05 | 公開日 | 2005-01-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance J.Mol.Biol., 345, 2005
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1TQE
| Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 | 分子名称: | Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B | 著者 | Chen, L, Han, A, He, J, Wu, Y, Liu, J.O. | 登録日 | 2004-06-17 | 公開日 | 2004-12-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2. J.Mol.Biol., 345, 2005
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2HFD
| NMR structure of protein Hydrogenase-1 operon protein hyaE from Escherichia coli: Northeast Structural Genomics Consortium Target ER415 | 分子名称: | Hydrogenase-1 operon protein hyaE | 著者 | Singarapu, K.K, Liu, G, Eletsky, A, Parish, D, Atreya, H.S, Xu, D, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-06-23 | 公開日 | 2006-08-22 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif. J.STRUCT.FUNCT.GENOM., 9, 2008
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3WJA
| The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form | 分子名称: | NADP-dependent malic enzyme | 著者 | Li, S.-Y, Chen, M.-C, Yang, P.-C, Chan, N.-L, Liu, J.-H, Hung, H.-C. | 登録日 | 2013-10-08 | 公開日 | 2014-08-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.548 Å) | 主引用文献 | Structural characteristics of the nonallosteric human cytosolic malic enzyme. Biochim.Biophys.Acta, 1844, 2014
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1Z25
| Structure of P.furiosus Argonaute with bound Mn2+ | 分子名称: | Argonaute, MANGANESE (II) ION | 著者 | Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. | 登録日 | 2005-03-07 | 公開日 | 2005-04-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Purified Argonaute2 and an siRNA form recombinant human RISC. Nat.Struct.Mol.Biol., 12, 2005
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1Z26
| Structure of Pyrococcus furiosus Argonaute with bound tungstate | 分子名称: | Argonaute, TUNGSTATE(VI)ION | 著者 | Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. | 登録日 | 2005-03-07 | 公開日 | 2005-04-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Purified Argonaute2 and an siRNA form recombinant human RISC. Nat.Struct.Mol.Biol., 12, 2005
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