6VRV

Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model

Summary for 6VRV

Entry DOI	10.2210/pdb6vrv/pdb
Descriptor	Serine/threonine-protein kinase pim-1, 4-chloro-1-{(1S)-1-[(3S)-3-fluoropyrrolidin-3-yl]ethyl}-3-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	inhibitor complex, oncoprotein, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32021.75
Authors	Barberis, C.E.,Batchelor, J.D.,Liu, J. (deposition date: 2020-02-10, release date: 2020-11-04, Last modification date: 2023-10-11)
Primary citation	Barberis, C.,Erdman, P.,Czekaj, M.,Fire, L.,Pribish, J.,Tserlin, E.,Maniar, S.,Batchelor, J.D.,Liu, J.,Patel, V.F.,Hebert, A.,Levit, M.,Wang, A.,Sun, F.,Huang, S.A. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg.Med.Chem.Lett., 30:127625-127625, 2020 Cited by PubMed: 33096160 DOI: 10.1016/j.bmcl.2020.127625 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation