6VRU

PIM-inhibitor complex 1

Summary for 6VRU

• Entry DOI: 10.2210/pdb6vru/pdb
• Descriptor: Serine/threonine-protein kinase pim-1, IMIDAZOLE, 3,4-dichloro-2-cyclopropyl-1-[(piperidin-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridine-6-carboxamide, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, oncoprotein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32100.28

Authors

Barberis, C.E.,Batchelor, J.D.,Mechin, I.,Liu, J. (deposition date: 2020-02-10, release date: 2020-11-04, Last modification date: 2023-10-11)

• Primary citation: Barberis, C.,Erdman, P.,Czekaj, M.,Fire, L.,Pribish, J.,Tserlin, E.,Maniar, S.,Batchelor, J.D.,Liu, J.,Patel, V.F.,Hebert, A.,Levit, M.,Wang, A.,Sun, F.,Huang, S.A.; Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model.; Bioorg.Med.Chem.Lett., 30:127625-127625, 2020; PubMed: 33096160; DOI: 10.1016/j.bmcl.2020.127625

Experimental method

X-RAY DIFFRACTION (2.07 Å)