2AEE
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![BU of 2aee by Molmil](/molmil-images/mine/2aee) | Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes | Descriptor: | CHLORIDE ION, GLYCEROL, Orotate phosphoribosyltransferase, ... | Authors: | Chang, C, Li, H, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-07-22 | Release date: | 2005-09-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes To be Published
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5F84
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6AYF
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![BU of 6ayf by Molmil](/molmil-images/mine/6ayf) | TRPML3/ML-SA1 complex at pH 7.4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-3 | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | Deposit date: | 2017-09-08 | Release date: | 2017-11-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
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8FOD
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![BU of 8fod by Molmil](/molmil-images/mine/8fod) | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOE
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![BU of 8foe by Molmil](/molmil-images/mine/8foe) | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOK
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![BU of 8fok by Molmil](/molmil-images/mine/8fok) | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FS5
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![BU of 8fs5 by Molmil](/molmil-images/mine/8fs5) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 3 (open 9-1-1 and stably bound chamber DNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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8FS4
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![BU of 8fs4 by Molmil](/molmil-images/mine/8fs4) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 2 (open 9-1-1 ring and flexibly bound chamber DNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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8FS3
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![BU of 8fs3 by Molmil](/molmil-images/mine/8fs3) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 1 (open 9-1-1 and shoulder bound DNA only) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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8FS8
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![BU of 8fs8 by Molmil](/molmil-images/mine/8fs8) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 5-nt gapped DNA (9-1-1 encircling fully bound DNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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8FS7
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![BU of 8fs7 by Molmil](/molmil-images/mine/8fs7) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 5 (closed 9-1-1 and stably bound chamber DNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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8FS6
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![BU of 8fs6 by Molmil](/molmil-images/mine/8fs6) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 4 (partially closed 9-1-1 and stably bound chamber DNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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7SH2
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![BU of 7sh2 by Molmil](/molmil-images/mine/7sh2) | Structure of the yeast Rad24-RFC loader bound to DNA and the open 9-1-1 clamp | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2021-10-07 | Release date: | 2022-03-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
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7SGZ
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![BU of 7sgz by Molmil](/molmil-images/mine/7sgz) | Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2021-10-07 | Release date: | 2022-03-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
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5F87
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4BM5
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![BU of 4bm5 by Molmil](/molmil-images/mine/4bm5) | Chloroplast inner membrane protein TIC110 | Descriptor: | SIMILAR TO CHLOROPLAST INNER MEMBRANE PROTEIN TIC110 | Authors: | Tsai, J.-Y, Chu, C.-C, Yeh, Y.-H, Chen, L.-J, Li, H.-m, Hsiao, C.-D. | Deposit date: | 2013-05-06 | Release date: | 2013-06-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Structural Characterizations of Chloroplast Translocon Protein Tic110. Plant J., 75, 2013
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4HK4
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![BU of 4hk4 by Molmil](/molmil-images/mine/4hk4) | Crystal structure of apo Tyrosine-tRNA ligase mutant protein | Descriptor: | DI(HYDROXYETHYL)ETHER, Tyrosine--tRNA ligase | Authors: | Yu, Y, Zhou, Q, Dong, J, Li, J, Xiaoxuan, L, Mukherjee, A, Ouyang, H, Nilges, M, Li, H, Gao, F, Gong, W, Lu, Y, Wang, J. | Deposit date: | 2012-10-15 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Crystal structure of apo Tyrosine-tRNA ligase mutant protein To be Published
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4HPW
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![BU of 4hpw by Molmil](/molmil-images/mine/4hpw) | Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine | Descriptor: | 3-methoxy-L-tyrosine, Tyrosine--tRNA ligase | Authors: | Yu, Y, Zhou, Q, Dong, J, Li, J, Xiaoxuan, L, Mukherjee, A, Ouyang, H, Nilges, M, Li, H, Gao, F, Gong, W, Lu, Y, Wang, J. | Deposit date: | 2012-10-24 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine To be Published
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1PKF
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![BU of 1pkf by Molmil](/molmil-images/mine/1pkf) | Crystal Structure of Epothilone D-bound Cytochrome P450epoK | Descriptor: | EPOTHILONE D, PROTOPORPHYRIN IX CONTAINING FE, cytochrome p450EpoK | Authors: | Nagano, S, Li, H, Shimizu, H, Nishida, C, Ogura, H, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2003-06-05 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Epothilone D-bound, Epothilone B-bound, and Substrate-free Forms of Cytochrome P450epoK J.Biol.Chem., 278, 2003
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1Q5D
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![BU of 1q5d by Molmil](/molmil-images/mine/1q5d) | Epothilone B-bound Cytochrome P450epoK | Descriptor: | 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE, P450 epoxidase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Nagano, S, Li, H, Shimizu, H, Nishida, C, Ogura, H, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2003-08-06 | Release date: | 2003-10-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK J.Biol.Chem., 278, 2003
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1Q5E
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![BU of 1q5e by Molmil](/molmil-images/mine/1q5e) | Substrate-free Cytochrome P450epoK | Descriptor: | P450 epoxidase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Nagano, S, Li, H, Shimizu, H, Nishida, C, Ogura, H, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2003-08-06 | Release date: | 2003-10-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK J.Biol.Chem., 278, 2003
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6PP4
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![BU of 6pp4 by Molmil](/molmil-images/mine/6pp4) | Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(3-(Aminomethyl)-4-(pyridin-3-ylmethoxy)phenyl)-4-methylquinolin-2-amine | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 7-{3-(aminomethyl)-4-[(pyridin-3-yl)methoxy]phenyl}-4-methylquinolin-2-amine, ... | Authors: | Chreifi, G, Li, H, Poulos, T.L. | Deposit date: | 2019-07-05 | Release date: | 2020-04-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020
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6P2R
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![BU of 6p2r by Molmil](/molmil-images/mine/6p2r) | Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor | Descriptor: | (3R)-3,31-dimethyl-7,11,15,19,23,27-hexamethylidenedotriacont-31-en-1-yl dihydrogen phosphate, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bai, L, Li, H. | Deposit date: | 2019-05-21 | Release date: | 2019-07-10 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex. Nat.Struct.Mol.Biol., 26, 2019
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8G6F
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![BU of 8g6f by Molmil](/molmil-images/mine/8g6f) | Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs | Descriptor: | (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide, Proteasome endopeptidase complex, Proteasome subunit alpha type-1, ... | Authors: | Hsu, H.-C, Li, H. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun, 14, 2023
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8G6E
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![BU of 8g6e by Molmil](/molmil-images/mine/8g6e) | Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304 | Descriptor: | (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide, Proteasome subunit alpha type, Proteasome subunit alpha type-1, ... | Authors: | Hsu, H.-C, Li, H. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (2.18 Å) | Cite: | Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun, 14, 2023
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