4LZD
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![BU of 4lzd by Molmil](/molmil-images/mine/4lzd) | Human DNA polymerase mu- Apoenzyme | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA-directed DNA/RNA polymerase mu, ... | Authors: | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | Deposit date: | 2013-07-31 | Release date: | 2014-02-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
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3QRK
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![BU of 3qrk by Molmil](/molmil-images/mine/3qrk) | The crystal structure of human abl1 kinase domain in complex with DP-987 | Descriptor: | (3S)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, Tyrosine-protein kinase ABL1 | Authors: | Chan, W.W, Wise, S.C, Kaufman, M.D, Ahn, Y.M, Ensinger, C.L, Haack, T, Hood, M.M, Jones, J, Lord, J.W, Lu, W.P, Miller, D, Patt, W.C, Smith, B.D, Petillo, P.A, Rutkoski, T.J, Telikepalli, H, Vogeti, L, Yao, T, Chun, L, Clark, R, Evangelista, P, Gavrilescu, L.C, Lazarides, K, Zaleskas, V.M, Stewart, L.J, Van Etten, R.A, Flynn, D.L. | Deposit date: | 2011-02-18 | Release date: | 2011-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036. Cancer Cell, 19, 2011
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4JVL
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![BU of 4jvl by Molmil](/molmil-images/mine/4jvl) | Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and estradiol (E2) | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-3'-5'-DIPHOSPHATE, ESTRADIOL, ... | Authors: | Gosavi, R.A, Knudsen, G.A, Birnbaum, L.S, Pedersen, L.C. | Deposit date: | 2013-03-25 | Release date: | 2013-09-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.943 Å) | Cite: | Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis. Environ.Health Perspect., 121, 2013
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4KHS
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![BU of 4khs by Molmil](/molmil-images/mine/4khs) | |
4KSE
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![BU of 4kse by Molmil](/molmil-images/mine/4kse) | Crystal structure of a HIV p51 (219-230) deletion mutant | Descriptor: | 1,2-ETHANEDIOL, HIV p51 subunit | Authors: | Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E. | Deposit date: | 2013-05-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.677 Å) | Cite: | Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation. Nucleic Acids Res., 42, 2014
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4KHQ
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![BU of 4khq by Molmil](/molmil-images/mine/4khq) | Ternary complex of RB69 mutant L415F wit DUMPNPP | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ... | Authors: | Clausen, A.R, Pedersen, L.C. | Deposit date: | 2013-05-01 | Release date: | 2013-10-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.186 Å) | Cite: | Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
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3R0W
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![BU of 3r0w by Molmil](/molmil-images/mine/3r0w) | Crystal Structures of Multidrug-resistant HIV-1 Protease in Complex with Mechanism-Based Aspartyl Protease Inhibitors. | Descriptor: | Multidrug-resistant clinical isolate 769 HIV-1 Protease, N-[(2R)-1-{[(2S,3S)-5-{[(2R)-1-{[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino}-3-chloro-1-oxopropan-2-yl]amino}-3-hydroxy-5-oxo-1-phenylpentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]pyridine-2-carboxamide | Authors: | Yedidi, R.S, Gupta, D, Liu, Z, Brunzelle, J, Kovari, I.A, Woster, P.M, Kovari, L.C. | Deposit date: | 2011-03-09 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds. Biochem.Biophys.Res.Commun., 421, 2012
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2KZT
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![BU of 2kzt by Molmil](/molmil-images/mine/2kzt) | Structure of the Tandem MA-3 Region of Pdcd4 | Descriptor: | Programmed cell death protein 4 | Authors: | Waters, L.C, Strong, S.L, Oka, O, Muskett, F.W, Veverka, V, Banerjee, S, Schmedt, T, Henry, A.J, Klempnauer, K.H, Carr, M.D. | Deposit date: | 2010-06-24 | Release date: | 2011-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor J.Biol.Chem., 286, 2011
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2L73
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![BU of 2l73 by Molmil](/molmil-images/mine/2l73) | |
3PJ6
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![BU of 3pj6 by Molmil](/molmil-images/mine/3pj6) | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants | Descriptor: | HIV protease | Authors: | Yedidi, R.S, Proteasa, G, Martinez-Cajas, J.L, Vickrey, J.F, Martin, P.D, Wawrzak, Z, Kovari, L.C. | Deposit date: | 2010-11-08 | Release date: | 2011-04-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants. Acta Crystallogr.,Sect.D, 67, 2011
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4LZG
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![BU of 4lzg by Molmil](/molmil-images/mine/4lzg) | Binary complex of human DNA Polymerase Mu with DNA | Descriptor: | CHLORIDE ION, DNA-directed DNA/RNA polymerase mu, GLYCEROL, ... | Authors: | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | Deposit date: | 2013-07-31 | Release date: | 2014-02-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
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4LZT
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![BU of 4lzt by Molmil](/molmil-images/mine/4lzt) | ATOMIC RESOLUTION REFINEMENT OF TRICLINIC HEW LYSOZYME AT 295K | Descriptor: | LYSOZYME, NITRATE ION | Authors: | Walsh, M.A, Schneider, T, Sieker, L.C, Dauter, Z, Lamzin, V, Wilson, K.S. | Deposit date: | 1997-03-31 | Release date: | 1998-04-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Refinement of triclinic hen egg-white lysozyme at atomic resolution. Acta Crystallogr.,Sect.D, 54, 1998
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2WLW
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![BU of 2wlw by Molmil](/molmil-images/mine/2wlw) | Structure of the N-terminal capsid domain of HIV-2 | Descriptor: | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE | Authors: | Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. | Deposit date: | 2009-06-26 | Release date: | 2009-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
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2MWC
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2WJM
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![BU of 2wjm by Molmil](/molmil-images/mine/2wjm) | Lipidic sponge phase crystal structure of the photosynthetic reaction centre from Blastochloris viridis (low dose) | Descriptor: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | Authors: | Woehri, A.B, Wahlgren, W.Y, Malmerberg, E, Johansson, L.C, Neutze, R, Katona, G. | Deposit date: | 2009-05-27 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Lipidic sponge phase crystal structure of a photosynthetic reaction center reveals lipids on the protein surface. Biochemistry, 48, 2009
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4M5F
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![BU of 4m5f by Molmil](/molmil-images/mine/4m5f) | complex structure of Tse3-Tsi3 | Descriptor: | CALCIUM ION, PHOSPHATE ION, Uncharacterized protein | Authors: | Gu, L.C. | Deposit date: | 2013-08-08 | Release date: | 2014-04-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
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2X5V
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![BU of 2x5v by Molmil](/molmil-images/mine/2x5v) | 80 microsecond laue diffraction snapshot from crystals of a photosynthetic reaction centre 3 millisecond following photoactivation. | Descriptor: | BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, FE (II) ION, ... | Authors: | Wohri, A.B, Katona, G, Johansson, L.C, Fritz, E, Malmerberg, E, Andersson, M, Vincent, J, Eklund, M, Cammarata, M, Wulff, M, Davidsson, J, Groenhof, G, Neutze, R. | Deposit date: | 2010-02-10 | Release date: | 2010-05-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Light-Induced Structural Changes in a Photosynthetic Reaction Center Caught by Laue Diffraction. Science, 328, 2010
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2WLV
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![BU of 2wlv by Molmil](/molmil-images/mine/2wlv) | Structure of the N-terminal capsid domain of HIV-2 | Descriptor: | GAG POLYPROTEIN | Authors: | Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. | Deposit date: | 2009-06-26 | Release date: | 2009-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
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3PML
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![BU of 3pml by Molmil](/molmil-images/mine/3pml) | crystal structure of a polymerase lambda variant with a dGTP analog opposite a templating T | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]guanosine, 5'-D(*CP*AP*GP*TP*AP*C)-3', 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3', ... | Authors: | Bebenek, K, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2010-11-17 | Release date: | 2011-01-26 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Replication infidelity via a mismatch with Watson-Crick geometry. Proc.Natl.Acad.Sci.USA, 108, 2011
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2XFH
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![BU of 2xfh by Molmil](/molmil-images/mine/2xfh) | Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole. | Descriptor: | 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, DIMETHYL SULFOXIDE, ERYTHROMYCIN B/D C-12 HYDROXYLASE, ... | Authors: | Savino, C, Montemiglio, L.C, Gianni, S, Vallone, B. | Deposit date: | 2010-05-24 | Release date: | 2010-09-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States. Biochemistry, 49, 2010
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2NMM
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![BU of 2nmm by Molmil](/molmil-images/mine/2nmm) | Crystal structure of human phosphohistidine phosphatase. Northeast Structural Genomics Consortium target HR1409 | Descriptor: | 14 kDa phosphohistidine phosphatase, SULFATE ION | Authors: | Kuzin, A.P, Abashidze, M, Forouhar, F, Seetharaman, J, Kent, C, Fang, Y, Cunningham, K, Conover, K, Ma, L.C, Xiao, R, Acton, T, Montelione, G, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-10-22 | Release date: | 2007-01-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of human phosphohistidine phosphatase. Northeast Structural Genomics Consortium target HR1409 To be Published
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4M0A
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![BU of 4m0a by Molmil](/molmil-images/mine/4m0a) | Human DNA Polymerase Mu post-catalytic complex | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA-directed DNA/RNA polymerase mu, ... | Authors: | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | Deposit date: | 2013-08-01 | Release date: | 2014-02-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
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3QRI
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![BU of 3qri by Molmil](/molmil-images/mine/3qri) | The crystal structure of human abl1 kinase domain in complex with DCC-2036 | Descriptor: | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, SODIUM ION, Tyrosine-protein kinase ABL1 | Authors: | Chan, W.W, Wise, S.C, Kaufman, M.D, Ahn, Y.M, Ensinger, C.L, Haack, T, Hood, M.M, Jones, J, Lord, J.W, Lu, W.P, Miller, D, Patt, W.C, Smith, B.D, Petillo, P.A, Rutkoski, T.J, Telikepalli, H, Vogeti, L, Yao, T, Chun, L, Clark, R, Evangelista, P, Gavrilescu, L.C, Lazarides, K, Zaleskas, V.M, Stewart, L.J, Van Etten, R.A, Flynn, D.L. | Deposit date: | 2011-02-18 | Release date: | 2011-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036. Cancer Cell, 19, 2011
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4MGW
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![BU of 4mgw by Molmil](/molmil-images/mine/4mgw) | Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence | Descriptor: | ClC containing Dickerson-Drew dodecamer, MAGNESIUM ION | Authors: | Theruvathu, J.A, Whitney, Y, Montgomery Pettitt, B, Sowers, L.C. | Deposit date: | 2013-08-29 | Release date: | 2013-11-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence. Biochemistry, 52, 2013
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4LQW
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![BU of 4lqw by Molmil](/molmil-images/mine/4lqw) | |