2XFH

Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.

Replaces:  2VRV

Summary for 2XFH

• Entry DOI: 10.2210/pdb2xfh/pdb
• Related: 2JJN 2JJO 2JJP 2VRV 2WIO
• Descriptor: ERYTHROMYCIN B/D C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (5 entities in total)
• Functional Keywords: monoxygenase, erythromycin a biosynthesis, oxidoreductase
• Biological source: SACCHAROPOLYSPORA ERYTHRAEA
• Total number of polymer chains: 1
• Total formula weight: 46731.33

Authors

Savino, C.,Montemiglio, L.C.,Gianni, S.,Vallone, B. (deposition date: 2010-05-24, release date: 2010-09-29, Last modification date: 2023-12-20)

• Primary citation: Montemiglio, L.C.,Gianni, S.,Vallone, B.,Savino, C.; Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.; Biochemistry, 49:9199-, 2010; PubMed: 20845962; DOI: 10.1021/BI101062V

Experimental method

X-RAY DIFFRACTION (1.9 Å)