2XFH

Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.

Replaces:  2VRV

Summary for 2XFH

Related2WIO 2JJN 2VRV 2JJP 2JJO
DescriptorERYTHROMYCIN B/D C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (5 entities in total)
Functional Keywordsmonoxygenase, erythromycin a biosynthesis, oxidoreductase
Biological sourceSACCHAROPOLYSPORA ERYTHRAEA
Total number of polymer chains1
Total molecular weight46731.33
Authors
Savino, C.,Montemiglio, L.C.,Gianni, S.,Vallone, B. (deposition date: 2010-05-24, release date: 2010-09-29, Last modification date: 2014-02-05)
Primary citation
Montemiglio, L.C.,Gianni, S.,Vallone, B.,Savino, C.
Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.
Biochemistry, 49:9199-, 2010
PubMed: 20845962 (PDB entries with the same primary citation)
DOI: 10.1021/BI101062V
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229160.5%3.0%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution