2XFH

Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.

Replaces:  2VRV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ERYTHROMYCIN B/D C-12 HYDROXYLASE	polymer	411	45347.0	1	UniProt (P48635) Pfam (PF00067) In PDB	SACCHAROPOLYSPORA ERYTHRAEA	CYTOCROME P450 CYP113A1, CYTOCHROME P450 113A1
2	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
3	A	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE	non-polymer		344.8	2	Chemie (CL6)
4	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
5		water	water		18.0	388	Chemie (HOH)

Sequence modifications

A: 16 - 411 (UniProt: P48635)

PDB	External Database	Details
Met 1	-	expression tag
Phe 2	-	expression tag
Ala 3	-	expression tag
Asp 4	-	expression tag
Val 5	-	expression tag
Glu 6	-	expression tag
Thr 7	-	expression tag
Thr 8	-	expression tag
Cys 9	-	expression tag
Cys 10	-	expression tag
Ala 11	-	expression tag
Arg 12	-	expression tag
Arg 13	-	expression tag
Thr 14	-	expression tag
Leu 15	-	expression tag
Leu 344	Phe 330	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45347.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1384.3
All*	Total formula weight	46731.3

*Water molecules are not included.