2JJO

Structure of cytochrome P450 EryK in complex with its natural substrate erD

Summary for 2JJO

Related2VRU 2WIO 2JJN 2VRV 2JJP
DescriptorCYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, Erythromycin D, ... (4 entities in total)
Functional Keywordsiron, heme, monooxygenase, metal-binding, antibiotic biosynthesis, tie-rod mechanism of action, oxidoreductase, substrate specificity
Biological sourceSACCHAROPOLYSPORA ERYTHRAEA
Total number of polymer chains1
Total molecular weight46667.42
Authors
Savino, C.,Sciara, G.,Miele, A.E.,Kendrew, S.G.,Vallone, B. (deposition date: 2008-04-15, release date: 2009-07-14, Last modification date: 2013-02-06)
Primary citation
Savino, C.,Montemiglio, L.C.,Sciara, G.,Miele, A.E.,Kendrew, S.G.,Jemth, P.,Gianni, S.,Vallone, B.
Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284:29170-, 2009
PubMed: 19625248 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M109.003590
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.99 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23350.3%3.7%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution