Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
A | 0017000 | biological_process | antibiotic biosynthetic process |
A | 0020037 | molecular_function | heme binding |
A | 0033068 | biological_process | macrolide biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE HEM A 412 |
Chain | Residue |
A | ILE87 |
A | THR246 |
A | LEU249 |
A | MET291 |
A | ARG293 |
A | SER345 |
A | PHE346 |
A | GLY347 |
A | HIS351 |
A | CYS353 |
A | GLY355 |
A | HIS88 |
A | ALA359 |
A | EY5413 |
A | HOH2080 |
A | HOH2331 |
A | HOH2332 |
A | HOH2333 |
A | HIS95 |
A | ARG99 |
A | PHE106 |
A | LEU238 |
A | ALA241 |
A | GLY242 |
A | THR245 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE EY5 A 413 |
Chain | Residue |
A | HIS88 |
A | GLU89 |
A | LEU169 |
A | ILE172 |
A | MET174 |
A | PRO177 |
A | ILE186 |
A | LEU240 |
A | ALA241 |
A | THR245 |
A | PHE288 |
A | GLN292 |
A | HEM412 |
A | HOH2217 |
A | HOH2238 |
A | HOH2332 |
A | HOH2334 |
A | HOH2335 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGVHFCLG |
Chain | Residue | Details |
A | PHE346-GLY355 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
A | HIS88 | |
A | HIS95 | |
A | ARG99 | |
A | GLN292 | |
A | ARG293 | |
A | HIS351 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | CYS353 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1akd |
Chain | Residue | Details |
A | THR245 | |
A | ILE244 | |