4GGK
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![BU of 4ggk by Molmil](/molmil-images/mine/4ggk) | Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) bound to tungstate | Descriptor: | Mitochondrial cardiolipin hydrolase, TUNGSTATE(VI)ION, ZINC ION | Authors: | Ipsaro, J.J, Haase, A.D, Hannon, G.J, Joshua-Tor, L. | Deposit date: | 2012-08-06 | Release date: | 2012-10-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature, 491, 2012
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4GIF
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![BU of 4gif by Molmil](/molmil-images/mine/4gif) | C-terminal coiled-coil domain of transient receptor potential channel TRPP3 (PKD2L1, Polycystin-L) | Descriptor: | Polycystic kidney disease 2-like 1 protein | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Dobbins, S, Zhang, W.K, Tong, L, Isacoff, E.Y, Yang, J. | Deposit date: | 2012-08-08 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun, 3, 2012
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4GL0
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![BU of 4gl0 by Molmil](/molmil-images/mine/4gl0) | Putative spermidine/putrescine ABC transporter from Listeria monocytogenes | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Lmo0810 protein, ... | Authors: | Osipiuk, J, Zhou, M, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-08-13 | Release date: | 2012-08-22 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Putative spermidine/putrescine ABC transporter from Listeria monocytogenes To be Published
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4GLW
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![BU of 4glw by Molmil](/molmil-images/mine/4glw) | DNA ligase A in complex with inhibitor | Descriptor: | 7-methoxy-6-methylpteridine-2,4-diamine, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, ... | Authors: | Prade, L, Lange, R, Tidten-Luksch, N, Chambovey, A. | Deposit date: | 2012-08-15 | Release date: | 2012-10-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. Bioorg.Med.Chem.Lett., 22, 2012
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4GM3
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![BU of 4gm3 by Molmil](/molmil-images/mine/4gm3) | Crystal structure of human WD repeat domain 5 with compound MM-101 | Descriptor: | MM-101, WD repeat-containing protein 5 | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | Deposit date: | 2012-08-15 | Release date: | 2013-07-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.393 Å) | Cite: | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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4GPS
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![BU of 4gps by Molmil](/molmil-images/mine/4gps) | |
4GOY
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![BU of 4goy by Molmil](/molmil-images/mine/4goy) | The crystal structure of human fascin 1 K41A mutant | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | Authors: | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | Deposit date: | 2012-08-20 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
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4GPU
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4GUX
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![BU of 4gux by Molmil](/molmil-images/mine/4gux) | Crystal structure of trypsin:MCoTi-II complex | Descriptor: | ACETATE ION, CALCIUM ION, Cationic trypsin, ... | Authors: | King, G.J, Daly, N.L, Thorstholm, L, Greenwood, K.P, Rosengren, K.J, Heras, B, Craik, D.J, Martin, J.L. | Deposit date: | 2012-08-30 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor J.Biol.Chem., 288, 2013
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4GVV
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![BU of 4gvv by Molmil](/molmil-images/mine/4gvv) | Crystal Structure of de novo design serine hydrolase OSH55.27, Northeast Structural Genomics Consortium (NESG) Target OR246 | Descriptor: | De novo design serine hydrolase | Authors: | Kuzin, A, Lew, S, Seetharaman, J, Mao, M, Xiao, R, Kohan, E, Rajagopalan, S, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-08-31 | Release date: | 2012-09-12 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.895 Å) | Cite: | Northeast Structural Genomics Consortium Target OR246 To be Published
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4GW6
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![BU of 4gw6 by Molmil](/molmil-images/mine/4gw6) | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor | Descriptor: | (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid, ARSENIC, Gag-Pol polyprotein | Authors: | Feng, L, Kvaratskhelia, M. | Deposit date: | 2012-08-31 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors. J.Biol.Chem., 288, 2013
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8IXB
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![BU of 8ixb by Molmil](/molmil-images/mine/8ixb) | GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin seam region | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | Deposit date: | 2023-03-31 | Release date: | 2023-08-16 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
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8IXE
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![BU of 8ixe by Molmil](/molmil-images/mine/8ixe) | GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | Deposit date: | 2023-03-31 | Release date: | 2023-08-16 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
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8IXD
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![BU of 8ixd by Molmil](/molmil-images/mine/8ixd) | GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | Deposit date: | 2023-03-31 | Release date: | 2023-08-16 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
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8IXG
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![BU of 8ixg by Molmil](/molmil-images/mine/8ixg) | GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin seam region | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | Deposit date: | 2023-03-31 | Release date: | 2023-08-16 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
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8IXA
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![BU of 8ixa by Molmil](/molmil-images/mine/8ixa) | GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin non-seam region | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | Deposit date: | 2023-03-31 | Release date: | 2023-08-16 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
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8IXF
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![BU of 8ixf by Molmil](/molmil-images/mine/8ixf) | GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | Deposit date: | 2023-03-31 | Release date: | 2023-08-16 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
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4GX2
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![BU of 4gx2 by Molmil](/molmil-images/mine/4gx2) | GsuK channel bound to NAD | Descriptor: | CALCIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, ... | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | Deposit date: | 2012-09-03 | Release date: | 2012-12-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
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4H07
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![BU of 4h07 by Molmil](/molmil-images/mine/4h07) | Complex of G65T Myoglobin with Phenol in its Proximal Cavity | Descriptor: | 1,2-ETHANEDIOL, Myoglobin, PHENOL, ... | Authors: | Lebioda, L, Lovelace, L.L, Celeste, L.R, Huang, X, Wang, C, Shengfang, S, Dawson, J.H. | Deposit date: | 2012-09-07 | Release date: | 2012-11-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Complex of myoglobin with phenol bound in a proximal cavity. Acta Crystallogr.,Sect.F, 68, 2012
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4H3B
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![BU of 4h3b by Molmil](/molmil-images/mine/4h3b) | Crystal Structure of JNK3 in Complex with SAB Peptide | Descriptor: | Mitogen-activated protein kinase 10, SH3 domain-binding protein 5 | Authors: | Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. | Deposit date: | 2012-09-13 | Release date: | 2012-11-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
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4H3T
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![BU of 4h3t by Molmil](/molmil-images/mine/4h3t) | Crystal structure of CRISPR-associated protein Cse1 from Acidimicrobium ferrooxidans | Descriptor: | CRISPR-associated protein, Cse1 family, GLYCEROL | Authors: | Michalska, K, Stols, L, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2012-09-14 | Release date: | 2012-09-26 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of CRISPR-associated protein Cse1 from Acidimicrobium ferrooxidans To be Published
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4HBN
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![BU of 4hbn by Molmil](/molmil-images/mine/4hbn) | Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Xu, X, Marni, F, Wu, X, Su, Z, Musayev, F, Shrestha, S, Xie, C, Gao, W, Liu, Q, Zhou, L. | Deposit date: | 2012-09-28 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel. Structure, 20, 2012
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4GO3
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![BU of 4go3 by Molmil](/molmil-images/mine/4go3) | |
6ZAG
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![BU of 6zag by Molmil](/molmil-images/mine/6zag) | Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and ACV after exposure to dioxygen for 500ms. | Descriptor: | FE (II) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | Authors: | Rabe, P, Kamps, J.J.A.G, Sutherlin, K, Pharm, C, McDonough, M.A, Leissing, T.M, Aller, P, Butryn, A, Linyard, J, Lang, P, Brem, J, Fuller, F.D, Batyuk, A, Hunter, M.S, Pettinati, I, Clifton, I.J, Alonso-Mori, R, Gul, S, Young, I, Kim, I, Bhowmick, A, ORiordan, L, Brewster, A.S, Claridge, T.D.W, Sauter, N.K, Yachandra, V, Yano, J, Kern, J.F, Orville, A.M, Schofield, C.J. | Deposit date: | 2020-06-05 | Release date: | 2021-06-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4001 Å) | Cite: | X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis. Sci Adv, 7, 2021
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6ZAN
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![BU of 6zan by Molmil](/molmil-images/mine/6zan) | Isopenicillin N synthase in complex with Fe, the oxygen surrogate NO and ACV. | Descriptor: | FE (III) ION, Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | Authors: | Rabe, P, Kamps, J.J.A.G, Sutherlin, K, Pharm, C, McDonough, M.A, Leissing, T.M, Aller, P, Butryn, A, Linyard, J, Lang, P, Brem, J, Fuller, F.D, Batyuk, A, Hunter, M.S, Pettinati, I, Clifton, I.J, Alonso-Mori, R, Gul, S, Young, I, Kim, I, Bhowmick, A, ORiordan, L, Brewster, A.S, Claridge, T.D.W, Sauter, N.K, Yachandra, V, Yano, J, Kern, J.F, Orville, A.M, Schofield, C.J. | Deposit date: | 2020-06-05 | Release date: | 2021-06-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis. Sci Adv, 7, 2021
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