4GW6

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor

Summary for 4GW6

Entry DOI	10.2210/pdb4gw6/pdb
Related	1ITG 4GVM
Descriptor	Gag-Pol polyprotein, ARSENIC, (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid, ... (4 entities in total)
Functional Keywords	integrase, dde motif, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
Total number of polymer chains	1
Total formula weight	18525.09
Authors	Feng, L.,Kvaratskhelia, M. (deposition date: 2012-08-31, release date: 2013-05-01, Last modification date: 2024-02-28)
Primary citation	Feng, L.,Sharma, A.,Slaughter, A.,Jena, N.,Koh, Y.,Shkriabai, N.,Larue, R.C.,Patel, P.A.,Mitsuya, H.,Kessl, J.J.,Engelman, A.,Fuchs, J.R.,Kvaratskhelia, M. The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors. J.Biol.Chem., 288:15813-15820, 2013 Cited by PubMed: 23615903 DOI: 10.1074/jbc.M112.443390 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation