4GGK

Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) bound to tungstate

Summary for 4GGK

• Entry DOI: 10.2210/pdb4ggk/pdb
• Related: 1BYR 1BYS 4GGJ
• Descriptor: Mitochondrial cardiolipin hydrolase, ZINC ION, TUNGSTATE(VI)ION, ... (4 entities in total)
• Functional Keywords: pirna pathway, protein-rna interactions, pirna biogenesis, rna interference, rnai, hkd motif ccch zinc finger, nuclease, nucleic acid binding, outer mitochondrial membrane, hydrolase
• Biological source: Mus musculus (mouse)
• Cellular location: Mitochondrion outer membrane; Single-pass membrane protein: Q5SWZ9
• Total number of polymer chains: 1
• Total formula weight: 22656.08

Authors

Ipsaro, J.J.,Haase, A.D.,Hannon, G.J.,Joshua-Tor, L. (deposition date: 2012-08-06, release date: 2012-10-10, Last modification date: 2023-09-13)

• Primary citation: Ipsaro, J.J.,Haase, A.D.,Knott, S.R.,Joshua-Tor, L.,Hannon, G.J.; The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.; Nature, 491:279-283, 2012; PubMed: 23064227; DOI: 10.1038/nature11502

Experimental method

X-RAY DIFFRACTION (2.1 Å)