3G6G
 
 | | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations | | Descriptor: | GLYCEROL, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | | Deposit date: | 2009-02-06 | | Release date: | 2009-03-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
|
|
2F4J
 | | Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680 | | Descriptor: | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Proto-oncogene tyrosine-protein kinase ABL1 | | Authors: | Young, M.A, Shah, N.P, Chao, L.H, Zarrinkar, P, Sawyers, P, Kuriyan, J. | | Deposit date: | 2005-11-23 | | Release date: | 2006-01-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer Res., 66, 2006
|
|
1SPS
 | |
3SOA
 | | Full-length human CaMKII | | Descriptor: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker | | Authors: | Chao, L.H, Kuriyan, J. | | Deposit date: | 2011-06-30 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.5501 Å) | | Cite: | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme.
Cell(Cambridge,Mass.), 146, 2011
|
|
1U4H
 | | Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex) | | Descriptor: | GLYCEROL, Heme-based Methyl-accepting Chemotaxis Protein, OXYGEN MOLECULE, ... | | Authors: | Pellicena, P, Karow, D.S, Boon, E.M, Marletta, M.A, Kuriyan, J. | | Deposit date: | 2004-07-25 | | Release date: | 2004-08-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
3D1E
 | | Crystal structure of E. coli sliding clamp (beta) bound to a polymerase II peptide | | Descriptor: | DNA polymerase III subunit beta, decamer from polymerase II C-terminal | | Authors: | Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M. | | Deposit date: | 2008-05-05 | | Release date: | 2008-07-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3D7U
 | | Structural basis for the recognition of c-Src by its inactivator Csk | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, Tyrosine-protein kinase CSK | | Authors: | Levinson, N.M, Seeliger, M.A, Cole, P.A, Kuriyan, J. | | Deposit date: | 2008-05-21 | | Release date: | 2008-08-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.111 Å) | | Cite: | Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
|
|
2FO0
 | | Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase | | Descriptor: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... | | Authors: | Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J. | | Deposit date: | 2006-01-12 | | Release date: | 2006-03-21 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21, 2006
|
|
1U55
 | | Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex) | | Descriptor: | CHLORIDE ION, Heme-based Methyl-accepting Chemotaxis Protein, OXYGEN MOLECULE, ... | | Authors: | Pellicena, P, Karow, D.S, Boon, E.M, Marletta, M.A, Kuriyan, J. | | Deposit date: | 2004-07-27 | | Release date: | 2004-08-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
3D1G
 | | Structure of a small molecule inhibitor bound to a DNA sliding clamp | | Descriptor: | DNA polymerase III subunit beta, [(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid | | Authors: | Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M. | | Deposit date: | 2008-05-05 | | Release date: | 2008-07-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3D7T
 | | Structural basis for the recognition of c-Src by its inactivator Csk | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, STAUROSPORINE, Tyrosine-protein kinase CSK | | Authors: | Levinson, N.M, Seeliger, M.A, Cole, P.A, Kuriyan, J. | | Deposit date: | 2008-05-21 | | Release date: | 2008-08-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.899 Å) | | Cite: | Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
|
|
1SXJ
 | | Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Activator 1 37 kDa subunit, Activator 1 40 kDa subunit, ... | | Authors: | Bowman, G.D, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2004-03-30 | | Release date: | 2004-06-22 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex.
Nature, 429, 2004
|
|
3DQX
 | | chicken c-Src kinase domain in complex with ATPgS | | Descriptor: | ADENOSINE MONOPHOSPHATE, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | | Deposit date: | 2008-07-09 | | Release date: | 2008-09-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nat.Struct.Mol.Biol., 15, 2008
|
|
1SPR
 | |
1U56
 | | Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (Water-ligated, ferric form) | | Descriptor: | CHLORIDE ION, Heme-based Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Pellicena, P, Karow, D.S, Boon, E.M, Marletta, M.A, Kuriyan, J. | | Deposit date: | 2004-07-27 | | Release date: | 2004-08-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
2GS2
 | | Crystal Structure of the active EGFR kinase domain | | Descriptor: | Epidermal growth factor receptor | | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | | Deposit date: | 2006-04-25 | | Release date: | 2006-06-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell(Cambridge,Mass.), 125, 2006
|
|
2GS6
 | | Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate | | Descriptor: | CHLORIDE ION, Epidermal growth factor receptor, Peptide, ... | | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | | Deposit date: | 2006-04-25 | | Release date: | 2006-06-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Cell(Cambridge,Mass.), 125, 2006
|
|
3U61
 | | Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2011-10-11 | | Release date: | 2012-01-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
|
|
2GS7
 | | Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP | | Descriptor: | Epidermal growth factor receptor, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | | Deposit date: | 2006-04-25 | | Release date: | 2006-06-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Cell(Cambridge,Mass.), 125, 2006
|
|
3TF1
 | | Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon | | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | Deposit date: | 2011-08-15 | | Release date: | 2011-11-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.0369 Å) | | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3TFF
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L67W mutant | | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | Deposit date: | 2011-08-15 | | Release date: | 2011-11-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9401 Å) | | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3TF0
 | | Crystal structure of an H-NOX protein from T. tengcongensis | | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | Deposit date: | 2011-08-15 | | Release date: | 2011-11-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.743 Å) | | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3TFE
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant under 6 atm of xenon | | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | Deposit date: | 2011-08-15 | | Release date: | 2011-11-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.991 Å) | | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
2HCK
 | | SRC FAMILY KINASE HCK-QUERCETIN COMPLEX | | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, CALCIUM ION, HEMATOPOETIC CELL KINASE HCK | | Authors: | Sicheri, F, Moarefi, I, Kuriyan, J. | | Deposit date: | 1997-02-25 | | Release date: | 1997-08-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the Src family tyrosine kinase Hck.
Nature, 385, 1997
|
|
2II0
 | | Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras | | Descriptor: | Son of sevenless homolog 1 | | Authors: | Freedman, T.S, Sondermann, H, Friedland, G.D, Kortemme, T, Bar-Sagi, D, Marqusee, S, Kuriyan, J. | | Deposit date: | 2006-09-27 | | Release date: | 2006-10-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
