3D1G

Structure of a small molecule inhibitor bound to a DNA sliding clamp

Summary for 3D1G

• Entry DOI: 10.2210/pdb3d1g/pdb
• Related: 2POL 3BEP 3D1E 3D1F
• Descriptor: DNA polymerase III subunit beta, [(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid (3 entities in total)
• Functional Keywords: chemical probe, dna polymerase, dna sliding clamp, dna replication, rational drug design, antibiotic target, transferase, transcription
• Biological source: Escherichia coli
• Cellular location: Cytoplasm : P0A988
• Total number of polymer chains: 2
• Total formula weight: 82259.41

Authors

Georgescu, R.E.,Yurieva, O.,Seung-Sup, K.,Kuriyan, J.,Kong, X.-P.,O'Donnell, M. (deposition date: 2008-05-05, release date: 2008-07-29, Last modification date: 2023-08-30)

• Primary citation: Georgescu, R.E.,Yurieva, O.,Kim, S.S.,Kuriyan, J.,Kong, X.P.,O'Donnell, M.; Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.; Proc.Natl.Acad.Sci.Usa, 105:11116-11121, 2008; PubMed: 18678908; DOI: 10.1073/pnas.0804754105

Experimental method

X-RAY DIFFRACTION (1.64 Å)