3D1G

Structure of a small molecule inhibitor bound to a DNA sliding clamp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030894	cellular_component	replisome
A	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
A	0042276	biological_process	error-prone translesion synthesis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044787	biological_process	bacterial-type DNA replication
A	1990078	cellular_component	replication inhibiting complex
A	1990085	cellular_component	Hda-beta clamp complex
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006974	biological_process	DNA damage response
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030894	cellular_component	replisome
B	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
B	0042276	biological_process	error-prone translesion synthesis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044787	biological_process	bacterial-type DNA replication
B	1990078	cellular_component	replication inhibiting complex
B	1990085	cellular_component	Hda-beta clamp complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 322 A 501

Chain	Residue
A	ARG152
B	HIS255
B	GLN355
A	THR172
A	PRO242
A	ASP243
A	SER346
A	MET362
B	ASN251
B	PRO252
B	ASP253

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 322 B 502

Chain	Residue
B	ARG152
B	TYR154
B	THR172
B	GLY174
B	SER346
B	ALA353
B	MET362

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:18191219

Chain	Residue	Details
A	ARG24
A	GLN149
A	TYR153
B	ARG24
B	GLN149
B	TYR153

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18191219

Chain	Residue	Details
A	ARG73
B	ARG73

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