7JTP
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![BU of 7jtp by Molmil](/molmil-images/mine/7jtp) | Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | Elongin-B, Elongin-C, GLYCEROL, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7JTO
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![BU of 7jto by Molmil](/molmil-images/mine/7jto) | Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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4R8U
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![BU of 4r8u by Molmil](/molmil-images/mine/4r8u) | S-SAD structure of DINB-DNA Complex | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA, DNA polymerase IV, ... | Authors: | Kottur, J, Nair, D.T, Weinert, T, Oligeric, V, Wang, M. | Deposit date: | 2014-09-03 | Release date: | 2015-01-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Fast native-SAD phasing for routine macromolecular structure determination Nat.Methods, 12, 2015
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8VCC
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![BU of 8vcc by Molmil](/molmil-images/mine/8vcc) | |
8U7B
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![BU of 8u7b by Molmil](/molmil-images/mine/8u7b) | |
7TW9
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![BU of 7tw9 by Molmil](/molmil-images/mine/7tw9) | |
7TW7
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![BU of 7tw7 by Molmil](/molmil-images/mine/7tw7) | |
7TW8
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![BU of 7tw8 by Molmil](/molmil-images/mine/7tw8) | |
8FRJ
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![BU of 8frj by Molmil](/molmil-images/mine/8frj) | Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946 | Descriptor: | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 chimera, ZINC ION | Authors: | Kottur, J, Aggarwal, A.K. | Deposit date: | 2023-01-07 | Release date: | 2023-07-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals. Plos Pathog., 19, 2023
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8FRK
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![BU of 8frk by Molmil](/molmil-images/mine/8frk) | |
4Q43
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![BU of 4q43 by Molmil](/molmil-images/mine/4q43) | Polymerase-damaged DNA complex | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*T*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*(RDG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kottur, J, Sharma, A, Nair, D.T. | Deposit date: | 2014-04-13 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic Structure, 23, 2015
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4Q45
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![BU of 4q45 by Molmil](/molmil-images/mine/4q45) | DNA Polymerase- damaged DNA complex | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*TP*CP*TP*A*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*GP*(RDG)P*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kottur, J, Sharma, A, Nair, D.T. | Deposit date: | 2014-04-13 | Release date: | 2015-05-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.176 Å) | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic Structure, 23, 2015
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6IG1
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![BU of 6ig1 by Molmil](/molmil-images/mine/6ig1) | DNA polymerase IV - DNA ternary complex 10 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN3, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2018-09-21 | Release date: | 2018-11-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res., 46, 2018
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5YUY
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![BU of 5yuy by Molmil](/molmil-images/mine/5yuy) | DNA polymerase IV - DNA ternary complex 9 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-10-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUR
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![BU of 5yur by Molmil](/molmil-images/mine/5yur) | DNA polymerase IV - DNA ternary complex 1 | Descriptor: | DNA polymerase IV, DTN, SODIUM ION, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.035 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUT
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![BU of 5yut by Molmil](/molmil-images/mine/5yut) | DNA polymerase IV - DNA ternary complex 3 | Descriptor: | DNA polymerase IV, DTN, MAGNESIUM ION, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-09-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUZ
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![BU of 5yuz by Molmil](/molmil-images/mine/5yuz) | DNA polymerase IV - DNA ternary complex 11 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res., 46, 2018
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5YYE
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![BU of 5yye by Molmil](/molmil-images/mine/5yye) | DNA polymerase IV - ternary complex 16 | Descriptor: | 5'-O-[hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]thymidine, DNA polymerase IV, DTN2, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-12-08 | Release date: | 2018-09-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.325 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUW
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![BU of 5yuw by Molmil](/molmil-images/mine/5yuw) | DNA polymerase IV - DNA ternary complex 6 | Descriptor: | DNA polymerase IV, DTN1, DTN2C, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.124 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YV1
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![BU of 5yv1 by Molmil](/molmil-images/mine/5yv1) | DNA polymerase IV - DNA ternary complex 13 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-09-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YV0
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![BU of 5yv0 by Molmil](/molmil-images/mine/5yv0) | DNA polymerase IV - DNA ternary complex 12 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res., 46, 2018
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5YUS
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![BU of 5yus by Molmil](/molmil-images/mine/5yus) | DNA polymerase IV - DNA ternary complex 2 | Descriptor: | DNA polymerase IV, DTN, MAGNESIUM ION, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5ZLV
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![BU of 5zlv by Molmil](/molmil-images/mine/5zlv) | |
5YV3
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![BU of 5yv3 by Molmil](/molmil-images/mine/5yv3) | DNA polymerase IV - DNA ternary complex 7 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUU
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![BU of 5yuu by Molmil](/molmil-images/mine/5yuu) | DNA polymerase IV - DNA ternary complex 4 | Descriptor: | DNA polymerase IV, DTN1, DTN2, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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