7TW8
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAH
Summary for 7TW8
Entry DOI | 10.2210/pdb7tw8/pdb |
Descriptor | Transcription factor ETV6,Proofreading exoribonuclease nsp14 chimera, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... (4 entities in total) |
Functional Keywords | n7-guanine methyl transferase, sars-cov-2, nsp14, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 1 |
Total formula weight | 35889.08 |
Authors | Kottur, J.,Aggarwal, A.K. (deposition date: 2022-02-06, release date: 2022-09-07, Last modification date: 2023-10-18) |
Primary citation | Kottur, J.,Rechkoblit, O.,Quintana-Feliciano, R.,Sciaky, D.,Aggarwal, A.K. High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Nat.Struct.Mol.Biol., 29:850-853, 2022 Cited by PubMed: 36075969DOI: 10.1038/s41594-022-00828-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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