7TW7

Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAM

Summary for 7TW7

Entry DOI	10.2210/pdb7tw7/pdb
Descriptor	Transcription factor ETV6,Proofreading exoribonuclease nsp14 chimera, ZINC ION, S-ADENOSYLMETHIONINE, ... (4 entities in total)
Functional Keywords	n7-guanine methyl transferase, sars-cov-2, nsp14, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	1
Total formula weight	35903.11
Authors	Kottur, J.,Aggarwal, A.K. (deposition date: 2022-02-06, release date: 2022-09-07, Last modification date: 2023-10-18)
Primary citation	Kottur, J.,Rechkoblit, O.,Quintana-Feliciano, R.,Sciaky, D.,Aggarwal, A.K. High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Nat.Struct.Mol.Biol., 29:850-853, 2022 Cited by PubMed: 36075969 DOI: 10.1038/s41594-022-00828-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation