7TW7
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transcription factor ETV6,Proofreading exoribonuclease nsp14 chimera | polymer | 309 | 35439.3 | 1 | UniProt (P41212) UniProt (P0DTD1) Pfam (PF02198) Pfam (PF06471) | Severe acute respiratory syndrome coronavirus 2 | ETS translocation variant 6,ETS-related protein Tel1,Tel,ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (58766358) PubChem (58633578) PubChem (87224684) PubChem (60038769) PubChem (131697735) PubChem (73897310) PubChem (5136) PubChem (145712080) PubChem (34755) PubChem (132988922) PubChem (9865603) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (12312798) PubChem (163046094) | |||
| 4 | D (A) | water | water | 18.0 | 342 | Chemie (HOH) |
Sequence modifications
A: 2 - 78 (UniProt: P41212)
A: 300 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 4 | Arg 49 | engineered mutation |
| Glu 67 | Val 112 | engineered mutation |
| Ala 77 | Lys 122 | engineered mutation |
| Pro 79 | - | linker |
| Ala 80 | - | linker |
| Ala 81 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35439.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 463.8 | |
| All* | Total formula weight | 35903.1 |
