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PDB: 39 results
4M47
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BU of 4m47 by Molmil
structure of human DNA polymerase complexed with 8-BrG in the template base paired with incoming non-hydrolyzable GTP
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA polymerase beta, MAGNESIUM ION, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-06
Release date:2014-01-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
4MF2
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BU of 4mf2 by Molmil
Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA
Descriptor: DNA polymerase beta, SODIUM ION, synthetic downstream primer, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-27
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4MF8
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BU of 4mf8 by Molmil
Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming CTP
Descriptor: DNA polymerase beta, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-27
Release date:2014-08-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structures of human DNA polymerase beta inserting bases opposite templating O6MG
To be Published
4JCH
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BU of 4jch by Molmil
OSH4 bound to an electrophilic oxysterol
Descriptor: (3beta,9beta,22R,25R)-3-hydroxyfurost-5-en-27-yl propanoate, Protein KES1
Authors:Koag, M.C, Kou, Y.I, Monzingo, A.F, Lee, S.
Deposit date:2013-02-21
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of OSH4 bound to an electrophilic oxysterol
To be Published
6UI2
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BU of 6ui2 by Molmil
Structure of human DNA polymerase eta complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(FMG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2019-09-30
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase eta.
Molecules, 24, 2019
4TUP
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BU of 4tup by Molmil
Structure of human DNA polymerase beta complexed with GG as the template (GG0b) in a 1-nucleotide gapped DNA
Descriptor: DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
4TUS
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BU of 4tus by Molmil
Human DNA polymerase beta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2) WITH MANGANESE IN THE ACTIVE SITE.
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
4TUR
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BU of 4tur by Molmil
Human DNA polymerase beta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2)
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.169 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
4TUQ
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BU of 4tuq by Molmil
Human DNA polymerase beta inserting dCMPNPP opposite GG template (GG0b).
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.367 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
5DB8
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BU of 5db8 by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the N7MG base paired with a dA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*(FMG)P*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.547 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
5EOZ
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BU of 5eoz by Molmil
Mutagenicity of 7-Benzyl guanine lesion and Replication by Human DNA Polymerase beta
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(GFL)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-11-10
Release date:2016-11-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Structural and kinetic studies of the effect of guanine-N7 alkylation and metal cofactors on DNA replication.
Biochemistry, 2018
5DB6
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BU of 5db6 by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the N7MG base paired with a dC
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*(FMG)P*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-20
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
5DBC
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BU of 5dbc by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the dG base paired with a dG
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*GP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
5DB7
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BU of 5db7 by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the N7MG base paired with a dT
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*(FMG)P*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.209 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
5DBB
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BU of 5dbb by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the dG base paired with a dA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
5DB9
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BU of 5db9 by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the N7MG base paired with a dG
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*GP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*(FMG)P*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
5DBA
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BU of 5dba by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the dG base paired with a dT
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.965 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
4M2Y
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BU of 4m2y by Molmil
Structure of human DNA polymerase beta complexed with 8-BrG as the template base in a 1-nucleotide gapped DNA
Descriptor: DNA polymerase beta, SODIUM ION, down-primer, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-05
Release date:2014-01-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
4MFA
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BU of 4mfa by Molmil
Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming TTP
Descriptor: DNA polymerase beta, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-27
Release date:2014-08-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structures of human DNA polymerase beta inserting bases opposite templating O6MG
To be Published
4O5C
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BU of 4o5c by Molmil
Structure of human DNA polymerase complexed with N7-MG as the template base in a 1-nucleotide gapped DNA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.363 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4MFC
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BU of 4mfc by Molmil
Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable CTP
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA polymerase beta, MAGNESIUM ION, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-27
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4MFF
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BU of 4mff by Molmil
Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable TTP
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA polymerase beta, MAGNESIUM ION, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-27
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4PGY
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BU of 4pgy by Molmil
Structure of human DNA polymerase beta complexed with a nicked DNA containing a GT at N-1 position and GC at N position
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-05-03
Release date:2015-05-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
4PHE
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BU of 4phe by Molmil
Structure of human DNA polymerase beta complexed with T in the template base paired with incoming non-hydrolyzable GTP
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-05-06
Release date:2015-05-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
4PGX
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BU of 4pgx by Molmil
Structure of human DNA polymerase beta complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-05-03
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.077 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015

 

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