5EOZ

Mutagenicity of 7-Benzyl guanine lesion and Replication by Human DNA Polymerase beta

Summary for 5EOZ

• Entry DOI: 10.2210/pdb5eoz/pdb
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(GFL)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... (8 entities in total)
• Functional Keywords: human dna polymerase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48285.63

Authors

Koag, M.C.,Lee, S. (deposition date: 2015-11-10, release date: 2016-11-23, Last modification date: 2023-09-27)

• Primary citation: Kou, Y.,Koag, M.C.,Lee, S.; Structural and kinetic studies of the effect of guanine-N7 alkylation and metal cofactors on DNA replication.; Biochemistry, 2018; PubMed: 29957995; DOI: 10.1021/acs.biochem.8b00331

Experimental method

X-RAY DIFFRACTION (2.088 Å)