4TUS
Human DNA polymerase beta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2) WITH MANGANESE IN THE ACTIVE SITE.
Summary for 4TUS
Entry DOI | 10.2210/pdb4tus/pdb |
Related | 4TUP 4TUQ 4TUR |
Descriptor | DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ... (9 entities in total) |
Functional Keywords | dna polymerase, transferase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 47570.68 |
Authors | Koag, M.C.,Lee, S. (deposition date: 2014-06-24, release date: 2014-10-01, Last modification date: 2024-03-13) |
Primary citation | Koag, M.C.,Lai, L.,Lee, S. Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta. J.Biol.Chem., 289:31341-31348, 2014 Cited by PubMed: 25237188DOI: 10.1074/jbc.M114.605451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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