8BD6
| Cas12k-sgRNA-dsDNA-TnsC non-productive complex. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cas12k, DNA, ... | 著者 | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | 登録日 | 2022-10-18 | 公開日 | 2022-12-28 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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6TUG
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5AF2
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4UN3
| Crystal structure of Cas9 bound to PAM-containing DNA target | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | 著者 | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | 登録日 | 2014-05-25 | 公開日 | 2014-07-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.593 Å) | 主引用文献 | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513, 2014
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4UN5
| Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3 | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | 著者 | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | 登録日 | 2014-05-25 | 公開日 | 2014-07-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513, 2014
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4UN4
| Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2 | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | 著者 | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | 登録日 | 2014-05-25 | 公開日 | 2014-07-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.371 Å) | 主引用文献 | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513, 2014
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4BK0
| Crystal structure of the KIX domain of human RECQL5 (domain-swapped dimer) | 分子名称: | ATP-DEPENDENT DNA HELICASE Q5, DI(HYDROXYETHYL)ETHER | 著者 | Kassube, S.A, Jinek, M, Fang, J, Tsutakawa, S, Nogales, E. | 登録日 | 2013-04-21 | 公開日 | 2013-06-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Mimicry in Transcription Regulation of Human RNA Polymerase II by the DNA Helicase Recql5 Nat.Struct.Mol.Biol., 20, 2013
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5L6D
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5L6E
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3ICQ
| Karyopherin nuclear state | 分子名称: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | 登録日 | 2009-07-18 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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3IBV
| Karyopherin cytosolic state | 分子名称: | CALCIUM ION, Exportin-T | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | 登録日 | 2009-07-17 | 公開日 | 2009-08-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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7Z4E
| SpCas9 bound to 8-nucleotide complementary DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 8 nucleotide complementary DNA substrate, Target strand of 8 nucleotide complementary DNA substrate, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-03-03 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4I
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7Z4C
| SpCas9 bound to 6 nucleotide complementary DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-03-03 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4H
| SpCas9 bound to 14-nucleotide complementary DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 14-nucleotide complementary DNA substrate, Target strand of 14-nucleotide complementary DNA substrate, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-03-03 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4J
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7Z4G
| SpCas9 bound to 12-nucleotide complementary DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-03-03 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4K
| SpCas9 bound to 10-nucleotide complementary DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-03-04 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4L
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7Z4D
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5NG6
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5NFV
| Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CRISPR-associated endonuclease Cpf1, DNA non-target strand, ... | 著者 | Swarts, D.C, van der Oost, J, Jinek, M. | 登録日 | 2017-03-16 | 公開日 | 2017-06-14 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. Mol. Cell, 66, 2017
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6FUW
| Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | 著者 | Clerici, M, Faini, M, Jinek, M. | 登録日 | 2018-02-28 | 公開日 | 2018-03-21 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex. Nat. Struct. Mol. Biol., 25, 2018
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6RW0
| Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase | 分子名称: | GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2019-06-03 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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5FQ5
| Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | 著者 | Olieric, V, Weinert, T, Finke, A, Anders, C, Jinek, M, Wang, M. | 登録日 | 2015-12-07 | 公開日 | 2016-03-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.136 Å) | 主引用文献 | Data-Collection Strategy for Challenging Native Sad Phasing. Acta Crystallogr.,Sect.D, 72, 2016
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