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PDB: 107 件
1W3B
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The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
分子名称: CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110
著者Jinek, M, Rehwinkel, J, Lazarus, B.D, Izaurralde, E, Hanover, J.A, Conti, E.
登録日2004-07-14
公開日2004-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha
Nat.Struct.Mol.Biol., 11, 2004
2J0A
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Structure of the catalytic domain of mouse Manic Fringe
分子名称: BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, POTASSIUM ION, SULFATE ION
著者Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E.
登録日2006-08-01
公開日2006-09-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2J0B
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Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese
分子名称: BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, MANGANESE (II) ION, POTASSIUM ION, ...
著者Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E.
登録日2006-08-01
公開日2006-09-04
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
4CMQ
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BU of 4cmq by Molmil
Crystal structure of Mn-bound S.pyogenes Cas9
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION
著者Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
登録日2014-01-17
公開日2014-02-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
4CMP
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Crystal structure of S. pyogenes Cas9
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION
著者Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
登録日2014-01-16
公開日2014-02-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
6F9S
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Crystal structure of the C-terminal RecA domain of DDX6 in complex with a conserved peptide from LSM14
分子名称: Cytokinesis, Apoptosis, RNA-associated, ...
著者Jinek, M, Brandmann, T.
登録日2017-12-15
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6FDL
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Crystal structure of the NYN domain of human MARF1
分子名称: Meiosis regulator and mRNA stability factor 1
著者Jinek, M, Brandmann, T.
登録日2017-12-26
公開日2018-11-07
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
6I1K
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BU of 6i1k by Molmil
Crystal structure of catalytically inactive FnCas12a in complex with a crRNA guide and a dsDNA target
分子名称: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas12a, DNA non-target strand (33-MER), ...
著者Jinek, M, Swarts, D.C.
登録日2018-10-29
公開日2019-01-23
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
2VXG
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Crystal structure of the conserved C-terminal region of Ge-1
分子名称: CG6181-PA, ISOFORM A
著者Jinek, M, Eulalio, A, Lingel, A, Helms, S, Conti, E, Izaurralde, E.
登録日2008-07-04
公開日2008-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The C-Terminal Region of Ge-1 Presents Conserved Structural Features Required for P-Body Localization.
RNA, 14, 2008
2X04
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BU of 2x04 by Molmil
Crystal structure of the PABC-TNRC6C complex
分子名称: POLYADENYLATE-BINDING PROTEIN 1, SULFATE ION, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN
著者Jinek, M, Fabian, M.R, Coyle, S.M, Sonenberg, N, Doudna, J.A.
登録日2009-12-04
公開日2010-01-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
2Y35
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Crystal structure of Xrn1-substrate complex
分子名称: DT11 (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', LD22664P, MAGNESIUM ION
著者Jinek, M, Coyle, S.M, Doudna, J.A.
登録日2010-12-18
公開日2011-03-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay.
Mol.Cell, 41, 2011
6I1L
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BU of 6i1l by Molmil
Crystal structure of FnCas12a in complex with a crRNA guide and ssDNA target
分子名称: CITRIC ACID, CRISPR-associated endonuclease Cas12a, MAGNESIUM ION, ...
著者Jinek, M, Swarts, D.C.
登録日2018-10-29
公開日2019-01-23
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
4C97
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Cas6 (TTHA0078) H37A mutant
分子名称: CAS6A, SULFATE ION
著者Jinek, M, Niewoehner, O, Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C98
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Thermus thermophilus Cas6 (TTHB231)
分子名称: CAS6B, ZINC ION
著者Jinek, M, Niewoehner, O, Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C8Y
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BU of 4c8y by Molmil
Cas6 (TTHA0078) substrate mimic complex
分子名称: CAS6A, R1 REPEAT RNA SUBSTRATE MIMIC, SULFATE ION
著者Jinek, M, Niewoehner, O, Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C9D
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Cas6 (TTHB231) product complex
分子名称: CAS6B, R3 REPEAT RNA CLEAVAGE PRODUCT
著者Jinek, M, Niewoehner, O, Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Nucleic Acids Res., 42, 2014
4C8Z
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Cas6 (TTHA0078) product complex
分子名称: CAS6A, POTASSIUM ION, R1 REPEAT RNA CLEAVAGE PRODUCT, ...
著者Jinek, M, Niewoehner, O, Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
7ZYH
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BU of 7zyh by Molmil
Crystal structure of human CPSF30 in complex with hFip1
分子名称: Cleavage and polyadenylation specificity factor subunit 4, Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1, ZINC ION
著者Muckenfuss, L.M, Jinek, M, Migenda Herranz, A.C, Clerici, M.
登録日2022-05-24
公開日2022-09-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
Elife, 11, 2022
9EZX
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BU of 9ezx by Molmil
Vibrio cholerae DdmD apo complex
分子名称: Helicase/UvrB N-terminal domain-containing protein
著者Loeff, L, Jinek, M.
登録日2024-04-14
公開日2024-06-19
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.55 Å)
主引用文献Molecular mechanism of plasmid elimination by the DdmDE defense system.
Science, 2024
7ZY4
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Crystal structure of human CstF77 in complex with hFip1
分子名称: Cleavage stimulation factor subunit 3, GLYCEROL, hFip1
著者Muckenfuss, L.M, Jinek, M.
登録日2022-05-23
公開日2022-09-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
Elife, 11, 2022
6RVZ
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Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate
分子名称: ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ...
著者Kroupova, A, Jinek, M.
登録日2019-06-03
公開日2020-05-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science, 369, 2020
6O16
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Crystal structure of murine DHX37 in complex with RNA
分子名称: DEAH (Asp-Glu-Ala-His) box polypeptide 37, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
著者Boneberg, F, Brandmann, T, Kobel, L, van den Heuvel, J, Bargsten, K, Bammert, L, Kutay, U, Jinek, M.
登録日2019-02-18
公開日2019-04-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.875 Å)
主引用文献Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.
Rna, 25, 2019
6QZK
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Structure of Clostridium butyricum Argonaute bound to a guide DNA (5' deoxycytidine) and a 19-mer target DNA
分子名称: Clostridium butyricum Argonaute, DNA target (5'-D(T*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*T)-3'), FORMIC ACID, ...
著者Swarts, D.C, Jinek, M, Hegge, J.W, Van der Oost, J.
登録日2019-03-11
公開日2019-04-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.548 Å)
主引用文献DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.
Nucleic Acids Res., 47, 2019
5L6D
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Crystal structure of the human METTL3-METTL14 complex bound to SAH
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
4UN5
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Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Niewoehner, O, Duerst, A, Jinek, M.
登録日2014-05-25
公開日2014-07-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014

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