2X04

Crystal structure of the PABC-TNRC6C complex

Summary for 2X04

Related1JGN 1JH4 1G9L 2DKL 1CVJ
DescriptorPOLYADENYLATE-BINDING PROTEIN 1, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN, SULFATE ION, ... (4 entities in total)
Functional Keywordspeptide-rna binding protein complex, rna-mediated gene silencing, nucleus, methylation, spliceosome, translation regulation, protein-protein complex, coiled coil, deadenylation, mrna splicing, phosphoprotein, mrna processing, microrna silencing, peptide/rna binding protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P11940
Total number of polymer chains4
Total molecular weight21566.78
Authors
Jinek, M.,Fabian, M.R.,Coyle, S.M.,Sonenberg, N.,Doudna, J.A. (deposition date: 2009-12-04, release date: 2010-01-19, Last modification date: 2011-07-13)
Primary citation
Jinek, M.,Fabian, M.R.,Coyle, S.M.,Sonenberg, N.,Doudna, J.A.
Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17:238-, 2010
PubMed: 20098421 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.1768
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.49 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.207130 1.9% 1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02