7XT8
| Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | Deposit date: | 2022-05-16 | Release date: | 2022-07-27 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
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8SGT
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8SGJ
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8H8J
| Lodoxamide-bound GPR35 in complex with G13 | Descriptor: | 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid), CALCIUM ION, CHOLESTEROL, ... | Authors: | Yuan, Q, Duan, J, Liu, Q, Xu, H.E, Jiang, Y. | Deposit date: | 2022-10-23 | Release date: | 2023-02-08 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell Discov, 8, 2022
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7RH9
| Cryo-EM structure of human rod CNGA1/B1 channel in apo state | Descriptor: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-16 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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8WZ2
| Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex | Descriptor: | G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y. | Deposit date: | 2023-11-01 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor. Cell Discov, 10, 2024
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8SGI
| Cryo-EM structure of human NCX1 in complex with SEA0400 | Descriptor: | 2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline, CALCIUM ION, Fab heavy chain, ... | Authors: | Xue, J, Jiang, Y. | Deposit date: | 2023-04-12 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mechanisms of human cardiac sodium calcium exchanger NCX1 To Be Published
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3NAF
| Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+ gated K+ Channel (BK Channel) | Descriptor: | Calcium-activated potassium channel subunit alpha-1,Calcium-activated potassium channel subunit alpha-1,Calcium-activated potassium channel subunit alpha-1 | Authors: | Wu, Y, Yang, Y, Ye, S, Jiang, Y. | Deposit date: | 2010-06-01 | Release date: | 2010-06-30 | Last modified: | 2017-06-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature, 466, 2010
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6YT1
| Mtb TMK crystal structure in complex with compound 26 | Descriptor: | 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase | Authors: | Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N. | Deposit date: | 2020-04-23 | Release date: | 2020-09-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur.J.Med.Chem., 206, 2020
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3R65
| MthK channel pore E92Q mutant | Descriptor: | Calcium-gated potassium channel mthK, POTASSIUM ION | Authors: | Shi, N, Zeng, W, Ye, S, Li, Y, Jiang, Y. | Deposit date: | 2011-03-21 | Release date: | 2012-02-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crucial points within the pore as determinants of K+ channel conductance and gating J.Mol.Biol., 411, 2011
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7WQ4
| Galanin-bound galanin receptor 2 in complex with Gq | Descriptor: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | Authors: | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-04-20 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7WQ3
| Galanin-bound galanin receptor 1 in complex with Gi | Descriptor: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | Authors: | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-04-20 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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4N6X
| Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 | Descriptor: | CHLORIDE ION, Na(+)/H(+) exchange regulatory cofactor NHE-RF1/Chemokine Receptor CXCR2 fusion protein | Authors: | Lu, G, Wu, Y, Jiang, Y, Brunzelle, J, Sirinupong, N, Li, C, Yang, Z. | Deposit date: | 2013-10-14 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.051 Å) | Cite: | New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping. Plos One, 8, 2013
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8UG4
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8UG5
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8UG6
| Mus musculus Otopetrin 2 (mOTOP2) in pH 5.0 | Descriptor: | Proton channel OTOP2 | Authors: | Gan, N, Jiang, Y. | Deposit date: | 2023-10-05 | Release date: | 2024-08-21 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural mechanism of proton conduction in otopetrin proton channel. Nat Commun, 15, 2024
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8UGA
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8UG7
| Mus musculus Otopetrin 2 (mOTOP2) in pH 8.0 | Descriptor: | Proton channel OTOP2 | Authors: | Gan, N, Jiang, Y. | Deposit date: | 2023-10-05 | Release date: | 2024-08-21 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural mechanism of proton conduction in otopetrin proton channel. Nat Commun, 15, 2024
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8UG8
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7RHH
| Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHG
| Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHJ
| Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state | Descriptor: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHL
| Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil | Descriptor: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHI
| Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHK
| Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state | Descriptor: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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