4N6X

Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Summary for 4N6X

Entry DOI	10.2210/pdb4n6x/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF1/Chemokine Receptor CXCR2 fusion protein, CHLORIDE ION (3 entities in total)
Functional Keywords	cxcr2, nherf1, neutrophil, inflammatory diseases, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): O14745
Total number of polymer chains	1
Total formula weight	10002.13
Authors	Lu, G.,Wu, Y.,Jiang, Y.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. (deposition date: 2013-10-14, release date: 2014-01-15, Last modification date: 2024-02-28)
Primary citation	Jiang, Y.,Lu, G.,Trescott, L.R.,Hou, Y.,Guan, X.,Wang, S.,Stamenkovich, A.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping. Plos One, 8:e81904-e81904, 2013 Cited by PubMed: 24339979 DOI: 10.1371/journal.pone.0081904 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.051 Å)

Structure validation