1VRW
| Crystal structure analysis of plasmodium falciparum enoyl-acyl-carrier-protein reductase with nadh | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ENOYL-ACYL CARRIER REDUCTASE | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2005-06-30 | 公開日 | 2005-07-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
|
|
3OEY
| Crystal structure of InhA_T266E:NADH complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Molle, V, Gulten, G, Vilcheze, C, Veyron-Churlet, R, Zanella-Cleon, I, Sacchettini, J.C, Jacobs Jr, W.R, Kremer, L. | 登録日 | 2010-08-13 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol.Microbiol., 78, 2010
|
|
3OEW
| Crystal structure of wild-type InhA:NADH complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Molle, V, Gulten, G, Vilcheze, C, Veyron-Churlet, R, Zanella-Cleon, I, Sacchettini, J.C, Jacobs Jr, W.R, Kremer, L. | 登録日 | 2010-08-13 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol.Microbiol., 78, 2010
|
|
3OF2
| Crystal structure of InhA_T266D:NADH complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Molle, V, Gulten, G, Vilcheze, C, Veyron-Churlet, R, Zanella-Cleon, I, Sacchettini, J.C, Jacobs Jr, W.R, Kremer, L. | 登録日 | 2010-08-13 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol.Microbiol., 78, 2010
|
|
1ZID
| |
1HKW
| MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LysA) | 分子名称: | DIAMINOPIMELATE DECARBOXYLASE, SULFATE ION | 著者 | Gokulan, K, Rupp, B, Pavelka Jr, M.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-03-11 | 公開日 | 2003-03-18 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of Mycobacterium Tuberculosis Diaminopimelate Decarboxylase, an Essential Enzyme in Bacterial Lysine Biosynthesis J.Biol.Chem., 278, 2003
|
|
1HKV
| mycobacterium diaminopimelate dicarboxylase (lysa) | 分子名称: | DIAMINOPIMELATE DECARBOXYLASE, LYSINE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Gokulan, K, Rupp, B, Pavelka Jr, M.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-03-11 | 公開日 | 2003-03-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Mycobacterium Tuberculosis Diaminopimelate Decarboxylase, an Essential Enzyme in Bacterial Lysine Biosynthesis J.Biol.Chem., 278, 2003
|
|
2FOI
| Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. | 分子名称: | 4-(2,4-DICHLOROPHENOXY)-2'-METHYLBIPHENYL-3-OL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Freundlich, J.S, Shieh, H, Anderson, J.W, Kuo, M, Yu, M, Valderramos, J, Karagyozov, L, Tsai, H, Lucumi, E, Jacobs Jr, W.R, Schiehser, G.A, Jacobus, D.P, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2006-01-13 | 公開日 | 2007-01-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy. J.Biol.Chem., 282, 2007
|
|
1P45
| Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data | 分子名称: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN | 著者 | Kuo, M.R, Morbidoni, H.R, Alland, D, Sneddon, S.F, Gourlie, B.B, Staveski, M.M, Leonard, M, Gregory, J.S, Janjigian, A.D, Yee, C, Musser, J.M, Kreiswirth, B.N, Iwamoto, H, Perozzo, R, Jacobs Jr, W.R, Sacchettini, J.C, Fidock, D.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-04-21 | 公開日 | 2003-09-16 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J.Biol.Chem., 278, 2003
|
|
1P44
| Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data | 分子名称: | 5-{[4-(9H-FLUOREN-9-YL)PIPERAZIN-1-YL]CARBONYL}-1H-INDOLE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Kuo, M.R, Morbidoni, H.R, Alland, D, Sneddon, S.F, Gourlie, B.B, Staveski, M.M, Leonard, M, Gregory, J.S, Janjigian, A.D, Yee, C, Musser, J.M, Kreiswirth, B, Iwamoto, H, Perozzo, R, Jacobs Jr, W.R, Sacchettini, J.C, Fidock, D.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-04-21 | 公開日 | 2003-09-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J.Biol.Chem., 278, 2003
|
|
1NHW
| Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase | 分子名称: | 2-(2,4-DICHLORO-PHENYLAMINO)-PHENOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2002-12-19 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase Year J.Biol.Chem., 277, 2002
|
|
1NNU
| Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog | 分子名称: | 6-(4-CHLORO-2-HYDROXY-PHENOXY)-NAPHTHALEN-2-OL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2003-01-14 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
|
|
1NL3
| CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM | 分子名称: | PREPROTEIN TRANSLOCASE SECA 1 SUBUNIT | 著者 | Sharma, V, Arockiasamy, A, Ronning, D.R, Savva, C.G, Holzenburg, A, Braunstein, M, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-01-06 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of M. tuberculosis SecA, A Preprotein Translocating ATPase Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
1NKT
| CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Preprotein translocase secA 1 subunit | 著者 | Sharma, V, Arockiasamy, A, Ronning, D.R, Savva, C.G, Holzenburg, A, Braunstein, M, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-01-03 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Crystal Structure of M. tuberculosis SecA, A Preprotein Translocating ATPase Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
1NHG
| CRYSTAL STRUCTURE ANALYSIS OF PLASMODIUM FALCIPARUM ENOYL-ACYL-CARRIER-PROTEIN REDUCTASE WITH TRICLOSAN | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN, enoyl-acyl carrier reductase | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2002-12-19 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
|
|
1KPG
| Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and CTAB | 分子名称: | CARBONATE ION, CETYL-TRIMETHYL-AMMONIUM, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1, ... | 著者 | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2001-12-30 | 公開日 | 2002-01-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis J.Biol.Chem., 277, 2002
|
|
1KPI
| Crystal Structure of mycolic acid cyclopropane synthase CmaA2 complexed with SAH and DDDMAB | 分子名称: | CARBONATE ION, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2, DIDECYL-DIMETHYL-AMMONIUM, ... | 著者 | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2001-12-30 | 公開日 | 2002-01-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis J.Biol.Chem., 277, 2002
|
|
1KPH
| Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB | 分子名称: | CARBONATE ION, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1, DIDECYL-DIMETHYL-AMMONIUM, ... | 著者 | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2001-12-30 | 公開日 | 2002-01-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis J.Biol.Chem., 277, 2002
|
|
1KP9
| Crystal structure of mycolic acid cyclopropane synthase CmaA1, apo-form | 分子名称: | ACETIC ACID, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 | 著者 | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2001-12-30 | 公開日 | 2002-01-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis J.Biol.Chem., 277, 2002
|
|
1L1E
| Crystal Structure of Mycolic Acid Cyclopropane Synthase PcaA Complexed with S-adenosyl-L-homocysteine | 分子名称: | CARBONATE ION, S-ADENOSYL-L-HOMOCYSTEINE, mycolic acid synthase | 著者 | Huang, C.-C, Smith, C.V, Glickman, M.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-02-15 | 公開日 | 2002-03-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J.Biol.Chem., 277, 2002
|
|
1ZXL
| Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives | 分子名称: | N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Freundlich, J.S, Anderson, J.W, Sarantakis, D, Shieh, H.M, Yu, M, Lucumi, E, Kuo, M, Schiehser, G.A, Jacobus, D.P, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2005-06-08 | 公開日 | 2006-06-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives. Bioorg.Med.Chem.Lett., 15, 2005
|
|
1ZSN
| Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives | 分子名称: | 5-CHLORO-2-(2-CHLORO-4-NITROPHENOXY)PHENOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Freundlich, J.S, Anderson, J.W, Sarantakis, D, Shieh, H.M, Yu, M, Lucumi, E, Kuo, M, Schiehser, G.A, Jacobus, D.P, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2005-05-24 | 公開日 | 2006-05-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.992 Å) | 主引用文献 | Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives. Bioorg.Med.Chem.Lett., 15, 2005
|
|
1ZW1
| Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives | 分子名称: | 2-(4-AMINO-2-CHLOROPHENOXY)-5-CHLOROPHENOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Freundlich, J.S, Anderson, J.W, Sarantakis, D, Shieh, H.M, Yu, M, Lucumi, E, Kuo, M, Schiehser, G.A, Jacobus, D.P, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2005-06-03 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives. Bioorg.Med.Chem.Lett., 15, 2005
|
|
1ZXB
| Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives | 分子名称: | 3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)-N-METHYLBENZAMIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Freundlich, J.S, Anderson, J.W, Sarantakis, D, Shieh, H.M, Yu, M, Lucumi, E, Kuo, M, Schiehser, G.A, Jacobus, D.P, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2005-06-07 | 公開日 | 2006-06-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives. Bioorg.Med.Chem.Lett., 15, 2005
|
|
1ENY
| CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS | 分子名称: | ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 1995-01-27 | 公開日 | 1996-01-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science, 267, 1995
|
|