1ZSN

Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives

Summary for 1ZSN

Entry DOI	10.2210/pdb1zsn/pdb
Related	1NHD 1NHG 1NHW 1NNU 1ZW1 1ZXL
Descriptor	enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-CHLORO-2-(2-CHLORO-4-NITROPHENOXY)PHENOL (3 entities in total)
Functional Keywords	oxidoreductase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	2
Total formula weight	78118.95
Authors	Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.,Shieh, H.M.,Yu, M.,Lucumi, E.,Kuo, M.,Schiehser, G.A.,Jacobus, D.P.,Jacobs Jr., W.R.,Fidock, D.A.,Sacchettini, J.C. (deposition date: 2005-05-24, release date: 2006-05-30, Last modification date: 2023-08-23)
Primary citation	Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.,Shieh, H.M.,Yu, M.,Valderramos, J.C.,Lucumi, E.,Kuo, M.,Jacobs, W.R.,Fidock, D.A.,Schiehser, G.A.,Jacobus, D.P.,Sacchettini, J.C. Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives. Bioorg.Med.Chem.Lett., 15:5247-5252, 2005 Cited by PubMed: 16198563 DOI: 10.1016/j.bmcl.2005.08.044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.992 Å)

Structure validation