6UA2
| Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment reconstruction. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | Johnson, M.C, Kollman, J.M. | 登録日 | 2019-09-10 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
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6UAJ
| Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | Johnson, M.C, Kollman, J.M. | 登録日 | 2019-09-10 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
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6UC2
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1AR6
| P1/MAHONEY POLIOVIRUS, DOUBLE MUTANT V1160I +P1095S | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | 登録日 | 1997-08-11 | 公開日 | 1997-12-03 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1AR9
| P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | 登録日 | 1997-08-11 | 公開日 | 1997-12-03 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1BIO
| HUMAN COMPLEMENT FACTOR D IN COMPLEX WITH ISATOIC ANHYDRIDE INHIBITOR | 分子名称: | COMPLEMENT FACTOR D, GLYCEROL, ISATOIC ANHYDRIDE | 著者 | Jing, H, Babu, Y.S, Moore, D, Kilpatrick, J.M, Liu, X.-Y, Volanakis, J.E, Narayana, S.V.L. | 登録日 | 1998-06-18 | 公開日 | 1999-06-22 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J.Mol.Biol., 282, 1998
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2MBR
| MURB WILD TYPE, COMPLEX WITH ENOLPYRUVYL-UDP-N-ACETYLGLUCOSAMINE | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID | 著者 | Benson, T.E, Walsh, C.T, Hogle, J.M. | 登録日 | 1996-11-08 | 公開日 | 1997-04-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution. Biochemistry, 36, 1997
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6OL4
| Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, apo state | 分子名称: | GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Cui, D.S, Lipchock, J.M, Loria, J.P. | 登録日 | 2019-04-15 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
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8Q6K
| Human IgD Fab in complex with an orthosteric inhibitor of Phl p 7 | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Human IgD Fab heavy chain, ... | 著者 | Davies, A.M, Vester, S.K, McDonnell, J.M. | 登録日 | 2023-08-11 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor. Antibodies, 12, 2023
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4HL7
| Crystal structure of nicotinate phosphoribosyltransferase (target NYSGR-026035) from Vibrio cholerae | 分子名称: | Nicotinate phosphoribosyltransferase, SULFATE ION | 著者 | Mulichak, A.M, Sauder, J.M, Keefe, L.J, Burley, S.K, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2012-10-16 | 公開日 | 2012-11-14 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of nicotinate phosphoribosyltransferase (target NYSGR-026035) from Vibrio cholerae To be Published
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3QD0
| Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide | 分子名称: | (3S,6R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ... | 著者 | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | 登録日 | 2011-01-17 | 公開日 | 2011-03-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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6O87
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8QOE
| Inward-facing conformation of the ABC transporter BmrA | 分子名称: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | 著者 | Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M. | 登録日 | 2023-09-28 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains. J.Biol.Chem., 300, 2023
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4HJG
| Meditope-enabled trastuzumab | 分子名称: | Immunoglobulin G-binding protein A, Protein L fragment, Trastuzumab heavy chain, ... | 著者 | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | 登録日 | 2012-10-12 | 公開日 | 2013-10-09 | 最終更新日 | 2013-11-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HK2
| U7Ub25.2540 | 分子名称: | SULFATE ION, Ubiquitin | 著者 | Murray, J.M, Rouge, L. | 登録日 | 2012-10-14 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization to be published
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6OO2
| Vps4 with Cyclic Peptide Bound in the Central Pore | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ... | 著者 | Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P. | 登録日 | 2019-04-22 | 公開日 | 2019-08-21 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife, 8, 2019
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6OAM
| Crystal Structure of ChlaDUB2 DUB domain | 分子名称: | Deubiquitinase and deneddylase Dub2, Ubiquitin | 著者 | Hausman, J.M, Das, C. | 登録日 | 2019-03-17 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | 主引用文献 | The Two Deubiquitinating Enzymes fromChlamydia trachomatisHave Distinct Ubiquitin Recognition Properties. Biochemistry, 59, 2020
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6OF4
| Precursor ribosomal RNA processing complex, apo-state. | 分子名称: | CLP1_P domain-containing protein, Ribonuclease | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | 登録日 | 2019-03-28 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6OL3
| Crystal structure of an adenovirus virus-associated RNA | 分子名称: | Adenovirus Virus-Associated (VA) RNA I apical and central domains, POTASSIUM ION | 著者 | Hood, I.V, Gordon, J.M, Bou-Nader, C, Henderson, F.V, Bahmanjah, S, Zhang, J. | 登録日 | 2019-04-15 | 公開日 | 2019-07-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Crystal structure of an adenovirus virus-associated RNA. Nat Commun, 10, 2019
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4HPT
| Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. | 登録日 | 2012-10-24 | 公開日 | 2013-03-20 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
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4HPU
| Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide | 分子名称: | MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. | 登録日 | 2012-10-24 | 公開日 | 2013-03-20 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
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6OL2
| Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | 分子名称: | ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ... | 著者 | Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J. | 登録日 | 2019-04-15 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening To Be Published
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8PWH
| Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, Pertuzumab Fab light chain, ... | 著者 | Ruedas, R, Vuillemot, R, Tubiana, T, Winter, J.M, Pieri, L, Arteni, A.A, Samson, C, Jonic, J, Mathieu, M, Bressanelli, S. | 登録日 | 2023-07-20 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex. J.Struct.Biol., 216, 2024
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8QO4
| Conserved Structures and Dynamics in 5-Proximal Regions of Betacoronavirus RNA Genomes | 分子名称: | MERS-CoV-SL5 | 著者 | Moura, T.R, Purta, E, Bernat, A, Baulin, E, Mukherjee, S, Bujnicki, J.M. | 登録日 | 2023-09-28 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Conserved structures and dynamics in 5'-proximal regions of Betacoronavirus RNA genomes. Nucleic Acids Res., 52, 2024
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4HKQ
| XMRV reverse transcriptase in complex with RNA/DNA hybrid | 分子名称: | DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*A*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), RNA (5'-R(*AP*AP*CP*AP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*CP*AP*U)-3'), Reverse transcriptase/ribonuclease H p80 | 著者 | Nowak, E, Potrzebowski, W, Konarev, P.V, Rausch, J.W, Bona, M.K, Svergun, D.I, Bujnicki, J.M, Le Grice, S.F.J, Nowotny, M. | 登録日 | 2012-10-15 | 公開日 | 2013-02-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid Nucleic Acids Res., 41, 2013
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