4HJG

Meditope-enabled trastuzumab

Summary for 4HJG

Entry DOI	10.2210/pdb4hjg/pdb
Related	1N8Z 4HKZ
Descriptor	Trastuzumab light chain, Trastuzumab heavy chain, Immunoglobulin G-binding protein A, ... (5 entities in total)
Functional Keywords	monoclonal antibody, immune system, cancer therapeutic
Biological source	Homo sapiens More
Cellular location	Secreted, cell wall; Peptidoglycan-anchor (Potential): P0A015
Total number of polymer chains	4
Total formula weight	60395.99
Authors	Donaldson, J.M.,Zer, C.,Avery, K.N.,Bzymek, K.P.,Horne, D.A.,Williams, J.C. (deposition date: 2012-10-12, release date: 2013-10-09, Last modification date: 2013-11-06)
Primary citation	Donaldson, J.M.,Zer, C.,Avery, K.N.,Bzymek, K.P.,Horne, D.A.,Williams, J.C. Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 110:17456-17461, 2013 Cited by PubMed: 24101516 DOI: 10.1073/pnas.1307309110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation