4HKZ
Trastuzumab Fab complexed with Protein L and Protein A fragments
Summary for 4HKZ
| Entry DOI | 10.2210/pdb4hkz/pdb |
| Related | 1N8Z 4HJG |
| Descriptor | Trastuzumab light chain, Trastuzumab heavy chain, Immunoglobulin G-binding protein A, ... (6 entities in total) |
| Functional Keywords | monoclonal antibody, immune system, cancer therapeutic |
| Biological source | Homo sapiens More |
| Cellular location | Secreted, cell wall ; Peptidoglycan-anchor : P0A015 |
| Total number of polymer chains | 4 |
| Total formula weight | 59840.84 |
| Authors | Avery, K.N.,Zer, C.,Bzymek, K.P.,Williams, J.C. (deposition date: 2012-10-15, release date: 2013-10-09, Last modification date: 2017-11-15) |
| Primary citation | Donaldson, J.M.,Zer, C.,Avery, K.N.,Bzymek, K.P.,Horne, D.A.,Williams, J.C. Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 110:17456-17461, 2013 Cited by PubMed: 24101516DOI: 10.1073/pnas.1307309110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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