4HKQ

XMRV reverse transcriptase in complex with RNA/DNA hybrid

Summary for 4HKQ

DescriptorReverse transcriptase/ribonuclease H p80, RNA (5'-R(*AP*AP*CP*AP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*CP*AP*U)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*A*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), ... (4 entities in total)
Functional Keywordsprotein-dna-rna complex, reverse transcription, transcription-rna-dna complex, transcription/rna/dna
Biological sourceXenotropic MuLV-related virus (XMRV)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor (Potential). Matrix protein p15: Virion (Potential). Capsid protein p30: Virion (Potential). Nucleocapsid protein p10: Virion (Potential) A1Z651
Total number of polymer chains3
Total molecular weight90967.72
Authors
Nowak, E.,Potrzebowski, W.,Konarev, P.V.,Rausch, J.W.,Bona, M.K.,Svergun, D.I.,Bujnicki, J.M.,Le Grice, S.F.J.,Nowotny, M. (deposition date: 2012-10-15, release date: 2013-02-20, Last modification date: 2013-07-03)
Primary citation
Nowak, E.,Potrzebowski, W.,Konarev, P.V.,Rausch, J.W.,Bona, M.K.,Svergun, D.I.,Bujnicki, J.M.,Le Grice, S.F.,Nowotny, M.
Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Nucleic Acids Res., 41:3874-3887, 2013
PubMed: 23382176 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkt053
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.04 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.278241.4%5.9%1.7%0.59MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution