8PWH

Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex

Summary for 8PWH

• Entry DOI: 10.2210/pdb8pwh/pdb
• EMDB information: 17993
• Descriptor: Trastuzumab Fab light chain, Trastuzumab Fab heavy chain, Pertuzumab Fab light chain, ... (7 entities in total)
• Functional Keywords: erbb-2, pertuzumab, trastuzumab, ternary complex, protein, flexibility, continuous conformation, cryo-em, single particle analysis, structural protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 164744.64

Authors

Ruedas, R.,Vuillemot, R.,Tubiana, T.,Winter, J.M.,Pieri, L.,Arteni, A.A.,Samson, C.,Jonic, J.,Mathieu, M.,Bressanelli, S. (deposition date: 2023-07-20, release date: 2024-02-21)

• Primary citation: Ruedas, R.,Vuillemot, R.,Tubiana, T.,Winter, J.M.,Pieri, L.,Arteni, A.A.,Samson, C.,Jonic, J.,Mathieu, M.,Bressanelli, S.; Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.17 Å)