8PWH
Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Trastuzumab Fab light chain | polymer | 214 | 23466.0 | 1 | Homo sapiens | ||
| 2 | B (B) | Trastuzumab Fab heavy chain | polymer | 220 | 23425.2 | 1 | Homo sapiens | ||
| 3 | C (C) | Pertuzumab Fab light chain | polymer | 214 | 23548.2 | 1 | Homo sapiens | ||
| 4 | D (D) | Pertuzumab Fab heavy chain | polymer | 222 | 23674.5 | 1 | Homo sapiens | ||
| 5 | E (E) | Receptor tyrosine-protein kinase erbB-2 | polymer | 624 | 68794.1 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | |
| 6 | F, G (G, J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | H, I, J (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 162907.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 164744.6 |
