6SO3
| The interacting head motif in insect flight muscle myosin thick filaments | 分子名称: | Myosin 2 essential light chain striated muscle, Myosin 2 heavy chain striated muscle, Myosin 2 regulatory light chain striated muscle | 著者 | Morris, E.P, Knupp, C, Squire, J.M. | 登録日 | 2019-08-28 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | The Interacting Head Motif Structure Does Not Explain the X-Ray Diffraction Patterns in Relaxed Vertebrate (Bony Fish) Skeletal Muscle and Insect (Lethocerus) Flight Muscle. Biology (Basel), 8, 2019
|
|
6T0U
| Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ... | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | 登録日 | 2019-10-03 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
|
|
6T0S
| Bat Influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence | 分子名称: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | 登録日 | 2019-10-03 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
|
|
6T0N
| Bat Influenza A polymerase pre-initiation complex | 分子名称: | 3' vRNA, 5' vRNA, MAGNESIUM ION, ... | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | 登録日 | 2019-10-03 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
|
|
6U0W
| Crystal structure of Staphylococcal nuclease variant Delta+PHS K133M at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Jeliazkov, J.R, Robinson, A.C, Berger, J.M, Garcia-Moreno E, B, Gray, J.G. | 登録日 | 2019-08-15 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Toward the computational design of protein crystals with improved resolution. Acta Crystallogr D Struct Biol, 75, 2019
|
|
6TWW
| Variant W229D/F290W-19 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4) | 分子名称: | ACETATE ION, Beta-Lactamase (GNCA4), FORMIC ACID, ... | 著者 | Gavira, J.A, Risso, V, Sanchez-Ruiz, J.M, Romero-Rivera, A, Kamerlin, S.C.L. | 登録日 | 2020-01-13 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening. Chem Sci, 11, 2020
|
|
6TXD
| Variant W229D/F290W-12 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4) | 分子名称: | ACETATE ION, Beta lactamase (GNCA4-12), FORMIC ACID, ... | 著者 | Gavira, J.A, Risso, V, Sanchez-Ruiz, J.M, Romero-Rivera, A, Kamerlin, S.C.L. | 登録日 | 2020-01-14 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening. Chem Sci, 11, 2020
|
|
6U8N
| Human IMPDH2 treated with ATP, IMP, and NAD+. Fully extended filament segment reconstruction. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... | 著者 | Johnson, M.C, Kollman, J.M. | 登録日 | 2019-09-05 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
|
|
6TJV
| Structure of the NDH-1MS complex from Thermosynechococcus elongatus | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, BETA-CAROTENE, ... | 著者 | Schuller, J.M, Saura, P, Thiemann, J, Schuller, S.K, Gamiz-Hernandez, A.P, Kurisu, G, Nowaczyk, M.M, Kaila, V.R.I. | 登録日 | 2019-11-27 | 公開日 | 2020-02-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Redox-coupled proton pumping drives carbon concentration in the photosynthetic complex I. Nat Commun, 11, 2020
|
|
1AL2
| P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT V1160I | 分子名称: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | 著者 | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | 登録日 | 1997-06-09 | 公開日 | 1997-11-19 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
|
|
6TW1
| Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | 分子名称: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | 登録日 | 2020-01-11 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 2020
|
|
6U0X
| Crystal structure of Staphylococcal nuclease variant Delta+PHS Q123D at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Jeliazkov, J.R, Robinson, A.C, Berger, J.M, Garcia-Moreno E, B, Gray, J.G. | 登録日 | 2019-08-15 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Toward the computational design of protein crystals with improved resolution. Acta Crystallogr D Struct Biol, 75, 2019
|
|
6U1V
| Crystal structure of acyl-ACP/acyl-CoA dehydrogenase from allylmalonyl-CoA and FK506 biosynthesis, TcsD | 分子名称: | Acyl-CoA dehydrogenase domain-containing protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE | 著者 | Blake-Hedges, J.M, Pereira, J.H, Barajas, J.F, Adams, P.D, Keasling, J.D. | 登録日 | 2019-08-16 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Mechanism of Regioselectivity in an Unusual Bacterial Acyl-CoA Dehydrogenase. J.Am.Chem.Soc., 142, 2020
|
|
6UDQ
| Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament end reconstruction. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | Johnson, M.C, Kollman, J.M. | 登録日 | 2019-09-19 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
|
|
6ULU
| |
6U7H
| Cryo-EM structure of the HCoV-229E spike glycoprotein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, Z, Benlekbir, S, Rubinstein, J.L, Rini, J.M. | 登録日 | 2019-09-02 | 公開日 | 2019-11-13 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
|
|
6TCN
| Crystal structure of the omalizumab Fab - crystal form II | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
|
|
6S1B
| Crystal Structure of DYRK1A with small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ... | 著者 | Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M. | 登録日 | 2019-06-18 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Kinase Scaffold Repurposing in the Public Domain To be published
|
|
6S1I
| Crystal Structure of DYRK1A with small molecule inhibitor | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, TETRAETHYLENE GLYCOL, ... | 著者 | Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M. | 登録日 | 2019-06-18 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Mining Public Domain Data to Develop Selective DYRK1A Inhibitors. Acs Med.Chem.Lett., 11, 2020
|
|
6RZ5
| XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, OLEIC ACID, ... | 著者 | Luginina, A, Gusach, A, Marin, E, Mishin, A, Brouillette, R, Popov, P, Shiryaeva, A, Besserer-Offroy, E, Longpre, J.M, Lyapina, E, Ishchenko, A, Patel, N, Polovinkin, V, Safronova, N, Bogorodskiy, A, Edelweiss, E, Liu, W, Batyuk, A, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Cherezov, V. | 登録日 | 2019-06-12 | 公開日 | 2019-10-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Sci Adv, 5, 2019
|
|
6U7E
| HCoV-229E RBD Class III in complex with human APN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Tomlinson, A.C.A, Li, Z, Rini, J.M. | 登録日 | 2019-09-02 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
|
|
6U8E
| |
6UE0
| Crystal structure of dihydrodipicolinate synthase from Klebsiella pneumoniae bound to pyruvate | 分子名称: | 4-hydroxy-tetrahydrodipicolinate synthase, CHLORIDE ION, SULFATE ION | 著者 | Impey, R.E, Lee, M, Hawkins, D.A, Sutton, J.M, Panjikar, S, Perugini, M.A, Soares da Costa, T.P. | 登録日 | 2019-09-20 | 公開日 | 2020-02-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens. Febs Lett., 594, 2020
|
|
6UDO
| Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | Johnson, M.C, Kollman, J.M. | 登録日 | 2019-09-19 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
|
|
6UDP
| |