6U8E

Human IMPDH2 treated with ATP, IMP, and NAD+. Filament assembly interface reconstruction.

Summary for 6U8E

Entry DOI	10.2210/pdb6u8e/pdb
EMDB information	20687
Descriptor	Inosine-5'-monophosphate dehydrogenase 2, INOSINIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
Functional Keywords	metabolism, filament, allostery, adenine, guanine, biosynthetic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	459937.05
Authors	Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-04, release date: 2020-03-25, Last modification date: 2024-03-20)
Primary citation	Johnson, M.C.,Kollman, J.M. Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9:-, 2020 Cited by PubMed: 31999252 DOI: 10.7554/eLife.53243 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.03 Å)

Structure validation