6U8N
Human IMPDH2 treated with ATP, IMP, and NAD+. Fully extended filament segment reconstruction.
Summary for 6U8N
Entry DOI | 10.2210/pdb6u8n/pdb |
Related | 6U8E |
EMDB information | 20687 20688 |
Descriptor | Inosine-5'-monophosphate dehydrogenase 2, ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... (4 entities in total) |
Functional Keywords | metabolism, filament, allostery, adenine, guanine, biosynthetic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 16 |
Total formula weight | 919895.94 |
Authors | Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-05, release date: 2020-03-25, Last modification date: 2024-03-20) |
Primary citation | Johnson, M.C.,Kollman, J.M. Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9:-, 2020 Cited by PubMed: 31999252DOI: 10.7554/eLife.53243 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.29 Å) |
Structure validation
Download full validation report