6TXD

Variant W229D/F290W-12 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4)

Summary for 6TXD

• Entry DOI: 10.2210/pdb6txd/pdb
• Related: 5FQI 5FQK
• Descriptor: Beta lactamase (GNCA4-12), GLYCEROL, FORMIC ACID, ... (6 entities in total)
• Functional Keywords: hydrolase, antibiotic resistance, ancestral reconstructed
• Biological source: synthetic construct
• Total number of polymer chains: 3
• Total formula weight: 87743.43

Authors

Gavira, J.A.,Risso, V.,Sanchez-Ruiz, J.M.,Romero-Rivera, A.,Kamerlin, S.C.L. (deposition date: 2020-01-14, release date: 2020-06-03, Last modification date: 2024-01-24)

• Primary citation: Risso, V.A.,Romero-Rivera, A.,Gutierrez-Rus, L.I.,Ortega-Munoz, M.,Santoyo-Gonzalez, F.,Gavira, J.A.,Sanchez-Ruiz, J.M.,Kamerlin, S.C.L.; Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening.; Chem Sci, 11:6134-6148, 2020; PubMed: 32832059; DOI: 10.1039/d0sc01935f

Experimental method

X-RAY DIFFRACTION (2 Å)