6TWW

Variant W229D/F290W-19 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4)

Summary for 6TWW

Entry DOI	10.2210/pdb6tww/pdb
Related	5FQI 5FQK
Descriptor	Beta-Lactamase (GNCA4), FORMIC ACID, ACETATE ION, ... (7 entities in total)
Functional Keywords	hydrolase, antibiotic resistance, ancestral reconstructed
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	29343.02
Authors	Gavira, J.A.,Risso, V.,Sanchez-Ruiz, J.M.,Romero-Rivera, A.,Kamerlin, S.C.L. (deposition date: 2020-01-13, release date: 2020-06-03, Last modification date: 2024-01-24)
Primary citation	Risso, V.A.,Romero-Rivera, A.,Gutierrez-Rus, L.I.,Ortega-Munoz, M.,Santoyo-Gonzalez, F.,Gavira, J.A.,Sanchez-Ruiz, J.M.,Kamerlin, S.C.L. Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening. Chem Sci, 11:6134-6148, 2020 Cited by PubMed: 32832059 DOI: 10.1039/d0sc01935f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.38 Å)

Structure validation