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6TWW

Variant W229D/F290W-19 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4)

Functional Information from GO Data
ChainGOidnamespacecontents
A0008800molecular_functionbeta-lactamase activity
A0017001biological_processantibiotic catabolic process
A0030655biological_processbeta-lactam antibiotic catabolic process
A0046677biological_processresponse to antibiotic
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue FMT A 1401
ChainResidue
AARG275

site_idAC2
Number of Residues3
Detailsbinding site for residue ACT A 1402
ChainResidue
APRO226
AASP229
AHIS293

site_idAC3
Number of Residues3
Detailsbinding site for residue FMT A 1403
ChainResidue
ALYS111
AHOH1504
AHOH1734

site_idAC4
Number of Residues11
Detailsbinding site for residue GOL A 1404
ChainResidue
ATYR105
ASER130
AASN132
AASN170
ATHR237
AHOH1510
AHOH1514
AHOH1576
AHOH1689
ASER70
ALYS73

site_idAC5
Number of Residues5
Detailsbinding site for residue FMT A 1405
ChainResidue
AGLY41
AGLY42
AGLU267
AHOH1509
AHOH1529

site_idAC6
Number of Residues4
Detailsbinding site for residue FMT A 1406
ChainResidue
AASP176
APRO177
AHOH1547
AHOH1693

site_idAC7
Number of Residues6
Detailsbinding site for residue FMT A 1407
ChainResidue
AGLU35
ALYS38
AARG153
AHOH1508
AHOH1512
AHOH1577

site_idAC8
Number of Residues6
Detailsbinding site for residue FMT A 1408
ChainResidue
AARG94
AHIS112
AASP115
AGLY116
AGLU121
AHOH1558

site_idAC9
Number of Residues6
Detailsbinding site for residue MG A 1409
ChainResidue
AHIS256
AHIS293
AHOH1523
AHOH1732
AHOH1748
AHOH1755

site_idAD1
Number of Residues6
Detailsbinding site for residue NA A 1410
ChainResidue
ATHR96
ATYR97
AVAL113
AHOH1733
AHOH1762
AHOH1824

Functional Information from PROSITE/UniProt
site_idPS00146
Number of Residues16
DetailsBETA_LACTAMASE_A Beta-lactamase class-A active site. FpMCSTfKallAAAVL
ChainResidueDetails
APHE66-LEU81

227111

PDB entries from 2024-11-06

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