1X8K
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![BU of 1x8k by Molmil](/molmil-images/mine/1x8k) | Crystal structure of retinol dehydratase in complex with anhydroretinol and inactive cofactor PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, ANHYDRORETINOL, CALCIUM ION, ... | Authors: | Pakhomova, S, Buck, J, Newcomer, M.E. | Deposit date: | 2004-08-18 | Release date: | 2005-02-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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1X6O
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1XBI
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![BU of 1xbi by Molmil](/molmil-images/mine/1xbi) | High resolution structure of Methanocaldococcus jannaschii L7AE | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 50S ribosomal protein L7Ae | Authors: | Brown II, B.A, Suryadi, J, Lieberman, D.V, Tran, E.J, Maxwell, E.S. | Deposit date: | 2004-08-30 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Crystal Structure of the Methanocaldococcus jannaschii Multifunctional L7Ae RNA-Binding Protein Reveals an Induced-Fit Interaction with the Box C/D RNAs. Biochemistry, 44, 2005
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5DZD
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![BU of 5dzd by Molmil](/molmil-images/mine/5dzd) | Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide | Descriptor: | E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | Authors: | Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-25 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide To be Published
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1XDN
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![BU of 1xdn by Molmil](/molmil-images/mine/1xdn) | High resolution crystal structure of an editosome enzyme from trypanosoma brucei: RNA editing ligase 1 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA editing ligase MP52 | Authors: | Deng, J, Schnaufer, A, Salavati, R, Stuart, K.D, Hol, W.G. | Deposit date: | 2004-09-07 | Release date: | 2004-12-07 | Last modified: | 2014-09-10 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1. J.Mol.Biol., 343, 2004
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4PMW
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8GDO
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1X81
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![BU of 1x81 by Molmil](/molmil-images/mine/1x81) | Farnesyl transferase structure of Jansen compound | Descriptor: | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, Protein farnesyltransferase beta subunit, Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, ... | Authors: | Li, Q, Claiborne, A, Li, T, Hasvold, L, Stoll, V.S, Muchmore, S, Jakob, C.G, Gu, W, Cohen, J, Hutchins, C, Frost, D, Rosenberg, S.H, Sham, H.L. | Deposit date: | 2004-08-16 | Release date: | 2004-12-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors. Bioorg.Med.Chem.Lett., 14, 2004
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4P5Q
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![BU of 4p5q by Molmil](/molmil-images/mine/4p5q) | Human EphA3 Kinase domain in complex with quinoxaline derivatives | Descriptor: | 2-amino-1-(2-chlorophenyl)-N-(3-ethoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Ephrin type-A receptor 3 | Authors: | Dong, J, Caflisch, A. | Deposit date: | 2014-03-19 | Release date: | 2014-08-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation. J.Med.Chem., 57, 2014
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1XAP
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![BU of 1xap by Molmil](/molmil-images/mine/1xap) | Structure of the ligand binding domain of the Retinoic Acid Receptor beta | Descriptor: | 4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC ACID, Retinoic acid receptor beta | Authors: | Germain, P, Kammerer, S, Peluso-Iltis, C, Tortolani, D, Zusi, F.C, Starrett, J, Lapointe, P, Daris, J.P, Marinier, A, De Lera, A.R, Rochel, N, Gronemeyer, H. | Deposit date: | 2004-08-26 | Release date: | 2004-11-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Rational design of RAR-selective ligands revealed by RARbeta crystal structure Embo Rep., 5, 2004
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5E1B
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![BU of 5e1b by Molmil](/molmil-images/mine/5e1b) | Crystal structure of NRMT1 in complex with SPKRIA peptide | Descriptor: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-29 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev., 29, 2015
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4P7G
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![BU of 4p7g by Molmil](/molmil-images/mine/4p7g) | Rat apo-COMT, phosphate bound | Descriptor: | Catechol O-methyltransferase, PHOSPHATE ION, POTASSIUM ION | Authors: | Ehler, A, Benz, J, Schlatter, D, Rudolph, M.G. | Deposit date: | 2014-03-27 | Release date: | 2014-06-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Mapping the conformational space accessible to catechol-O-methyltransferase. Acta Crystallogr.,Sect.D, 70, 2014
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5E3D
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![BU of 5e3d by Molmil](/molmil-images/mine/5e3d) | Crystal structure of the human BRPF1 bromodomain in complex with SEED7 | Descriptor: | 2,8-dithioxo-1,2,3,7,8,9-hexahydro-6H-purin-6-one, NITRATE ION, Peregrin | Authors: | Zhu, J, Caflisch, A. | Deposit date: | 2015-10-02 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. J.Med.Chem., 59, 2016
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5E1P
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![BU of 5e1p by Molmil](/molmil-images/mine/5e1p) | Ca(2+)-Calmodulin from Paramecium tetraurelia qFit disorder model | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Calmodulin | Authors: | Lin, J, van den Bedem, H, Brunger, A.T, Wilson, M.A. | Deposit date: | 2015-09-29 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.01 Å) | Cite: | Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin. Acta Crystallogr D Struct Biol, 72, 2016
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5E3H
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![BU of 5e3h by Molmil](/molmil-images/mine/5e3h) | Structural Basis for RNA Recognition and Activation of RIG-I | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, GLYCEROL, ... | Authors: | Jiang, F, Miller, M.T, Marcotrigiano, J. | Deposit date: | 2015-10-02 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature, 479, 2011
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1XCO
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![BU of 1xco by Molmil](/molmil-images/mine/1xco) | Crystal Structure of a Phosphotransacetylase from Bacillus subtilis in complex with acetylphosphate | Descriptor: | ACETYLPHOSPHATE, Phosphate acetyltransferase, SULFATE ION | Authors: | Xu, Q.S, Jancarik, J, Lou, Y, Yokota, H, Adams, P, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-09-02 | Release date: | 2004-12-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal structures of a phosphotransacetylase from Bacillus subtilis and its complex with acetyl phosphate J.STRUCT.FUNCT.GENOM., 6, 2005
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4P83
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![BU of 4p83 by Molmil](/molmil-images/mine/4p83) | Structure of engineered PyrR protein (PURPLE PyrR) | Descriptor: | Engineered PyrR protein (Purple), URIDINE-5'-MONOPHOSPHATE | Authors: | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | Deposit date: | 2014-03-30 | Release date: | 2014-12-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
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4P8M
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![BU of 4p8m by Molmil](/molmil-images/mine/4p8m) | Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor QN114 | Descriptor: | (2R)-2-{[(2R)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propan-1-ol, 3-[(4-ethoxybenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Neres, J, Pojer, F, Cole, S.T. | Deposit date: | 2014-03-31 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
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1XJ4
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![BU of 1xj4 by Molmil](/molmil-images/mine/1xj4) | CO-bound structure of BjFixLH | Descriptor: | CARBON MONOXIDE, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Key, J, Moffat, K. | Deposit date: | 2004-09-22 | Release date: | 2005-03-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Deoxy and CO-Bound bjFixLH Reveal Details of Ligand Recognition and Signaling Biochemistry, 44, 2005
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1XK3
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![BU of 1xk3 by Molmil](/molmil-images/mine/1xk3) | NADPH- and Ascorbate-Supported Heme Oxygenase Reactions are Distinct. Regiospecificity of Heme Cleavage by the R183E Mutant | Descriptor: | Heme oxygenase 1, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Wang, J, Lad, L, Poulos, T.L, Ortiz de montellano, P.R. | Deposit date: | 2004-09-26 | Release date: | 2004-11-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant. J.Biol.Chem., 280, 2005
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8GQM
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8GQK
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8GQI
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5F9H
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![BU of 5f9h by Molmil](/molmil-images/mine/5f9h) | Crystal structure of RIG-I helicase-RD in complex with 24-mer 5' triphosphate hairpin RNA | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, ... | Authors: | Wang, C, Marcotrigiano, J, Miller, M, Jiang, F. | Deposit date: | 2015-12-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proc.Natl.Acad.Sci.USA, 113, 2016
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4PUF
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![BU of 4puf by Molmil](/molmil-images/mine/4puf) | Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1 | Descriptor: | E3 ubiquitin-protein ligase SlrP, Thioredoxin | Authors: | Zouhir, S, Bernal-Bayard, J, Cordero-Alba, M, Cardenal-Munoz, E, Guimaraes, B, Lazar, N, Ramos-Morales, F, Nessler, S. | Deposit date: | 2014-03-13 | Release date: | 2014-09-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.296 Å) | Cite: | The structure of the Slrp-Trx1 complex sheds light on the autoinhibition mechanism of the type III secretion system effectors of the NEL family. Biochem.J., 464, 2014
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